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  Abe Clark
Abe Clark    PhD
Exec Director and Professor - N Tx Eye Research Institute
 
Contact address  Cbh-453    
Department  North Texas Eye Research Institute
Email  Abe.Clark@unthsc.edu  
   
 
Professional Preparation
Doctor of Philosophy,  Microbiology,  Case Western Reserve Universit,  OH
Bachelor of Arts,  Biology,  Thiel College,  
 
Appointments   More...    Close... 
2009 - Current    Member    Leadership Team
2008 - Current    Director    The North Texas Eye Research Institute
2008 - Current    Graduate Advisor    Visual Sciences Program
2008 - Current    Member    GSBS Graduate Council
Current    Chair    GSBS Vision Graduate Education Committee
Current    Member    Leadership Development Institute (LDI)
0 - 2016    Member    GSBS Cell Biology & Anatomy Faculty Development Committee
2016    Member    GSBS Cell Biology & Anatomy Graduate Education Committee
2016    Member    GSBS Cell Biology & Anatomy - Faculty Search Committee
2013 - 2015    Chair    GSBS Promotion & Tenure Committee
2011    Member    GSBS Yorio Scholarship for 1st Year Students Selections Committee
 
Teaching   More...    Close... 
BMSC 6302  Integ Biomed Sci 2: Cell Biol  Fall 2009 - Summer 2016
BMSC 5310  Scientific Communications  Spring 2016
CBIM 6350  Ocular Pharmacology  Spring 2016
CBIM 5220  Current Topics in Visual Scien  Fall 2014 - Spring 2016
BMSC 6395  Doctoral Dissertation  Spring 2011 - Summer 2016
BMSC 5150  Laboratory Rotations  Fall 2009 - Spring 2016
CBIM 5120  Visual Sciences Seminar  Fall 2014 - Spring 2016
BMSC 5302  Integ Biomed Sci 2: Cell Biol  Fall 2010 - Fall 2015
BMSC 6998  Individual Research  Fall 2009 - Summer 2016
BMSC 5160  Biomedical Ethics  Fall 2012 - Fall 2015
CBIM 6320  Diseases of the Eye  Spring 2015
MEDE 7120  Honors Elective: Zoonotic Diseases  Spring 2014 Medical Term - Spring 2015 Medical Term
CBIM 5390  Special Problems  Spring 2015
CBIM 5391  Special Problems 2  Spring 2015
CBAN 5200  Introduction to Bioinformatics  Summer 2014
CBAN 5220  Current Topics in Visual Scien  Spring 2010 - Spring 2014
BMSC 6310  Grant Writing  Spring 2014
CBAN 5300  Intro to the Visual Sciences  Fall 2012 - Fall 2013
CBAN 6300  Scientific Writing  Fall 2013
CBAN 5390  Special Problems  Fall 2009 - Fall 2013
CBAN 5120  Visual Sciences Seminar  Fall 2009 - Spring 2014
BMSC 6390  Special Problems  Summer 2013
BMSC 6301  Integ Biomed Sci 1: Biochem  Fall 2011 - Fall 2012
CBAN 6320  Diseases of the Eye  Spring 2011 - Spring 2013
MEDE 7811  Musculoskeletal/Skin System 1  2009 - Fall 2011 Medical Term
PHRM 6350  Ocular Pharmacology  Spring 2010 - Spring 2012
BMSC 5390  Special Problems  Spring 2010 - Summer 2012
BMSC 5998  Ind Research for MS Students  Summer 2012
BMSC 5135  Intro to Fac Research Programs  Fall 2011
CBAN 5391  Special Problems 2  Summer 2011
PHRM 6360  Nuc Rec Superfamily  Fall 2010
BMSC 6391  Special Problems 2  Fall 2010
DPHT 7600  Human Anatomy with Lab  Fall 2010
MPAS 5610  Human Anatomy with Lab  Fall 2010
BMSC 5231  Intro Health Disp/Iss in U.S.  Fall 2009 - Fall 2010
BMSC 5730  Current Topics in Glaucoma  Fall 2008 - Spring 2009
BMSC 5650  Lab Rotations  Summer 2005 - Spring 2009
CGEN 5900  Special Problems  Summer 2009
BMSC 5610  Core II:Molecular Cell Biology  Fall 2007 - Fall 2008
CGEN 6050  Visual Sciences Seminar  Fall 2008 - Spring 2009
MUSC 9130  Musculoskeletal/Skin System 1  2008
BMSC 5530  Intro Health Disp/Iss in U.S.  Fall 2008
CGEN 6080  Diseases of the Eye  Spring 2009
BMSC 6940  Individual Research  Fall 2008 - Summer 2009
BMSC 5930  Individual Research: MS Stdnts  Summer 2006 - Fall 2006
BMSC 5950  Thesis  Spring 2006 - Fall 2006
BMSC 5900  Special Problems  Fall 2005
BMSC 5910  Special Problems  Summer 2005
 
Awards / Honors   More...    Close... 
2014  Outstanding Graduate Faculty Award      Graduate Student Association, UNTHSC
2013  President's Award for Education Excellence      UNTHSC
2013  President's Award for Research Excellence      UNTHSC
2012  President's Award for Research Excellence      UNTHSC
2012  President's Award for Education Excellence      UNTHSC
2011  Outstanding Graduate Faculty Award      Graduate Student Association, UNTHSC
2011  Golden Apple Teaching Award      Graduate Student Association, UNTHSC
2011  Elected Member      Glaucoma Research Society
2011  Elected member - Glaucoma Research Society      Glaucoma Research Society
2009  2008 WGA Prize for Glaucoma Research      World Glaucoma Association
2009  Fellow of ARVO      ARVO
2008  Sigma Xi      Sigma Xi
 
Student Advising   More...    Close... 
Daniel,Steffi Stephen  -  2015-12-16
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Lerma,Tanya  -  2015-09-01
Thesis Committee, GSBS Structural Anat & Rehab Srvs, Master of Science    UNT Health Science Center
Bermudez,Jaclyn Y  -  2015-08-31
Co-Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2015-08-31
Dissertation Committee, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2015-08-31
Dissertation Committee, GSBS Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
Webber,Hannah C  -  2015-08-31
Co-Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Mody,Avani Avanti  -  2015-08-31
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Montecchi-Palmer,Michela A  -  2015-08-31
Co-Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2015-08-31
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Silverman,Sean  -  2015-08-31
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2015-08-31
Dissertation Committee, GSBS Biomedical Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Hernandez,Humberto  -  2015-08-31
Co-Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Raychaudhuri,Urmimala  -  2015-08-31
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Patel,Gaurang Chandrakantbhai  -  2015-08-31
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Silverman,Sean  -  2015-08-31
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Wendt,Frank R  -  2015-08-21
University Member, GSBS Molecular Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Nolan,Michael Robert  -  2015-08-20
Thesis Committee, GSBS Molecular Genetics, Master of Science    UNT Health Science Center
Zascavage,Roxanne Richelle  -  2015-08-20
Dissertation Committee, GSBS Molecular Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Hernandez,Humberto  -  2015-05-07
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Patel,Gaurang Chandrakantbhai  -  2015-05-07
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Phatak,Nitasha Ramchandra  -  2015-03-23
Dissertation Committee, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Joshi,Chaitanya Ramesh  -  2014-12-03
Dissertation Committee, GSBS Cell Bio, Immuno and Microbio, PhD in Biomedical Sciences    UNT Health Science Center
Bermudez,Jaclyn Y  -  2014-12-03
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Thete,Mayuri Vijay  -  2014-12-03
Thesis Committee, GSBS Cell Bio, Immuno and Microbio, Master of Science    UNT Health Science Center
Mody,Avani Avanti  -  2014-11-07
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Belmares,Ricardo  -  2014-11-04
Dissertation Committee, GSBS Structural Anat & Rehab Srvs, PhD in Biomedical Sciences    UNT Health Science Center
Webber,Hannah C  -  2014-10-21
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Ormos,Andrea  -  2014-10-15
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Lerma,Tanya  -  2014-10-02
Dissertation Committee, GSBS Structural Anat & Rehab Srvs, PhD in Biomedical Sciences    UNT Health Science Center
Raychaudhuri,Urmimala  -  2014-09-12
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Ormos,Andrea  -  2014-09-05
Thesis Committee, GSBS Molecular Genetics, Master of Science    UNT Health Science Center
Belmares,Ricardo  -  2014-08-27
Dissertation Committee, GSBS Structural Anatomy, PhD in Biomedical Sciences    UNT Health Science Center
Park,Yong Hwan  -  2014-08-11
Dissertation Committee, GSBS Neurobiology of Aging, PhD in Biomedical Sciences    UNT Health Science Center
Park,Yong Hwan  -  2014-08-11
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Kpetemey,Marilyne Fleurette  -  2014-08-02
University Member, GSBS Biochemistry & Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
Nolan,Michael Robert  -  2014-08-02
Dissertation Committee, GSBS Molecular Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Duggal,Divya  -  2014-08-02
Dissertation Committee, GSBS Biochemistry & Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
Medina Ortiz,Wanda E  -  2014-08-02
Major Professor, GSBS Cell Bio, Immuno and Microbio, PhD in Biomedical Sciences    UNT Health Science Center
Burnley,Brittney N  -  2014-08-02
University Member, GSBS Cell Bio, Immuno and Microbio, PhD in Biomedical Sciences    UNT Health Science Center
Maji,Sayantan  -  2014-08-02
Dissertation Committee, GSBS Biochemistry & Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
Daniel,Steffi Stephen  -  2014-06-10
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Daniel,Steffi S  -  2014-06-10
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Daniel,Steffi S  -  2014-06-10
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Duggal,Divya  -  2014-04-25
Dissertation Committee, GSBS Biochem & Molecular Biology, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2014-01-15
Advisor, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2014-01-15
Advisor, GSBS Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2014-01-15
Advisor, GSBS Biomedical Sciences, PhD in Biomedical Sciences    UNT Health Science Center
McGrady,Nolan R  -  2014-01-15
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Choudhury,Shreyasi  -  2013-12-05
Dissertation Committee, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Choudhury,Shreyasi  -  2013-12-05
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Ferguson,Erin E  -  2013-11-22
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Jeffries,Andrea H  -  2013-10-11
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Student Name Withheld  -  2013-10-09
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2013-10-09
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2013-10-09
Dissertation Committee, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2013-10-09
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Medina Ortiz,Wanda E  -  2013-10-01
Major Professor, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2013-10-01
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Taylor II,Victor Wayne  -  2013-10-01
Dissertation Committee, GSBS Structural Anatomy, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2013-10-01
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Kpetemey,Marilyne Fleurette  -  2013-10-01
University Member, GSBS Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
Mott,Brittney N  -  2013-10-01
University Member, GSBS Microbiology & Immunology, PhD in Biomedical Sciences    UNT Health Science Center
Montecchi-Palmer,Michela A  -  2013-10-01
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Minton,Alena Zakreuskaya  -  2013-10-01
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Burnley,Brittney N  -  2013-10-01
University Member, GSBS Microbiology & Immunology, PhD in Biomedical Sciences    UNT Health Science Center
Montecchi-Palmer,Michela A  -  2013-10-01
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Minton,Alena Zakreuskaya  -  2013-10-01
Dissertation Committee, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2013-10-01
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2013-10-01
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Taylor II,Victor Wayne  -  2013-10-01
Dissertation Committee, GSBS Structural Anatomy, Doctor of Philosophy    UNT Health Science Center
Montecchi-Palmer,Michela A  -  2013-10-01
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Park,Yong Hwan  -  2013-10-01
Dissertation Committee, GSBS Neurobiology of Aging, Doctor of Philosophy    UNT Health Science Center
Minton,Alena Zakreuskaya  -  2013-10-01
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Minton,Alena Zakreuskaya  -  2013-10-01
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Medina Ortiz,Wanda E  -  2013-10-01
Major Professor, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Kpetemey,Marilyne Fleurette  -  2013-10-01
University Member, GSBS Cancer Biology, Doctor of Philosophy    UNT Health Science Center
Mott,Brittney N  -  2013-10-01
University Member, GSBS Microbiology & Immunology, Doctor of Philosophy    UNT Health Science Center
Mody,Avani Avanti  -  2013-10-01
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Mody,Avani Avanti  -  2013-10-01
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Montecchi-Palmer,Michela A  -  2013-10-01
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Smith,Ashley Dawn  -  2013-09-06
Dissertation Committee, GSBS Microbiology & Immunology, Doctor of Philosophy    UNT Health Science Center
Smith,Ashley Dawn  -  2013-09-06
Dissertation Committee, GSBS Microbiology & Immunology, PhD in Biomedical Sciences    UNT Health Science Center
Bermudez,Jaclyn Y  -  2013-06-10
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Bermudez,Jaclyn Y  -  2013-06-10
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Bermudez,Jaclyn Y  -  2013-06-10
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
McGrady,Nolan R  -  2013-01-15
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
McGrady,Nolan R  -  2013-01-15
Advisor, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
McGrady,Nolan R  -  2013-01-15
Advisor, GSBS Cancer Biology, Doctor of Philosophy    UNT Health Science Center
McGrady,Nolan R  -  2013-01-15
Advisor, GSBS Biomedical Sciences, Doctor of Philosophy    UNT Health Science Center
Naik,Monal  -  2012-11-28
Advisor, GSBS Visual Sciences, Master of Science    UNT Health Science Center
Naik,Monal  -  2012-11-28
Dissertation Committee, GSBS Visual Sciences, Master of Science    UNT Health Science Center
Student Name Withheld  -  2012-11-21
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Schmidt,Cheryl L  -  2012-11-21
University Member, GSBS Biochem & Molecular Biology, Master of Science    UNT Health Science Center
Student Name Withheld  -  2012-11-21
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2012-11-21
Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2012-11-21
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Hinze,Cheryl L  -  2012-11-21
University Member, GSBS Biochem & Molecular Biology, Master of Science    UNT Health Science Center
Dalwadi,Dhwanil Atul  -  2012-11-20
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Dalwadi,Dhwanil Atul  -  2012-11-20
Dissertation Committee, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
Neelam,Sudha  -  2012-11-02
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Neelam,Sudha  -  2012-11-02
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Maji,Sayantan  -  2012-05-24
Dissertation Committee, GSBS Cancer Biology, Doctor of Philosophy    UNT Health Science Center
Maji,Sayantan  -  2012-05-24
Dissertation Committee, GSBS Cancer Biology, PhD in Biomedical Sciences    UNT Health Science Center
Zascavage,Roxanne Richelle  -  2012-05-21
Dissertation Committee, GSBS Forensic Genetics, Doctor of Philosophy    UNT Health Science Center
Zascavage McEowen,Roxanne Richelle  -  2012-05-21
Dissertation Committee, GSBS Forensic Genetics, Doctor of Philosophy    UNT Health Science Center
Zascavage,Roxanne Richelle  -  2012-05-21
Dissertation Committee, GSBS Forensic Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Naik,Monal  -  2012-03-19
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Naik,Monal  -  2012-03-19
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Shinde,Vishal Madhukar  -  2012-01-30
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Shinde,Vishal Madhukar  -  2012-01-30
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Shinde,Vishal Madhukar  -  2012-01-30
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2012-01-30
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Shinde,Vishal Madhukar  -  2012-01-30
Dissertation Committee, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2012-01-30
Dissertation Committee, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2012-01-30
Dissertation Committee, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
Moty,Bridget Christen  -  2012-01-30
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2012-01-09
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Choudhury,Shreyasi  -  2012-01-09
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Choudhury,Shreyasi  -  2012-01-09
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Fitzgerald,Ashley Michelle  -  2011-11-23
Dissertation Committee, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Taylor,Ashley Fitzgerald  -  2011-11-23
Dissertation Committee, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Neelam,Sudha  -  2011-11-23
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Fitzgerald,Ashley Michelle  -  2011-11-23
Dissertation Committee, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Medina Ortiz,Wanda E  -  2011-09-20
Advisor, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2011-09-20
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2011-09-20
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Shinde,Vishal Madhukar  -  2011-09-19
Advisor, GSBS Visual Sciences, Master of Science    UNT Health Science Center
Kaur,Manmeet  -  2011-05-18
Dissertation Committee, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Kaur,Manmeet  -  2011-05-18
Dissertation Committee, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Tan,Cong  -  2011-04-27
University Member, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Tan,Cong  -  2011-04-27
University Member, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
Silverman,Sean  -  2011-02-23
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Silverman,Sean  -  2011-02-23
Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Park,Yong Hwan  -  2010-11-12
Dissertation Committee, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
Phatak,Nitasha  -  2010-10-28
Dissertation Committee, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Phatak,Nitasha  -  2010-10-28
Dissertation Committee, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Phatak,Nitasha Ramchandra  -  2010-10-28
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Phatak,Nitasha  -  2010-10-28
Advisor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Phatak,Nitasha  -  2010-10-28
Advisor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Jain,Ankur  -  2010-10-27
Major Professor, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Jain,Ankur  -  2010-10-27
Major Professor, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
McEowen,Roxanne R  -  2010-08-06
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Zascavage McEowen,Roxanne Richelle  -  2010-08-06
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Haas,Jamie Leigh  -  2010-07-21
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Gill,Jadie I  -  2010-07-07
Thesis Committee, GSBS Forensic Genetics, Master of Science    UNT Health Science Center
Luan,Tomy  -  2010-04-20
Co-Major Professor, GSBS Visual Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Luan,Tomy  -  2010-04-20
Co-Major Professor, GSBS Visual Sciences, Doctor of Philosophy    UNT Health Science Center
Daudt III,Donald Raymond  -  2009-09-09
University Member, GSBS Pharmacology & Neuroscience, Doctor of Philosophy    UNT Health Science Center
Thamake,Sanjay Iranna  -  2009-09-09
University Member, GSBS Biomedical Sciences, Doctor of Philosophy    UNT Health Science Center
Daudt III,Donald Raymond  -  2009-09-09
University Member, GSBS Pharmacology & Neuroscience, PhD in Biomedical Sciences    UNT Health Science Center
Thamake,Sanjay Iranna  -  2009-09-09
University Member, GSBS Biomedical Sciences, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2009-09-01
Thesis Committee, GSBS Cell Biology, Master of Science    UNT Health Science Center
Student Name Withheld  -  2009-07-20
Dissertation Committee, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Fields,Jerel Adam  -  2009-06-16
Dissertation Committee, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Fields,Jerel Adam  -  2009-06-16
Dissertation Committee, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2008-12-04
Dissertation Committee, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2008-12-04
Dissertation Committee, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Pippin,Cade Christian  -  2008-11-19
Thesis Committee, GSBS Cell Biology, Master of Science    UNT Health Science Center
Student Name Withheld  -  2008-08-21
Advisor, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Student Name Withheld  -  2008-08-21
Major Professor, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2008-08-21
Advisor, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2008-08-21
Advisor, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2008-08-21
Major Professor, GSBS Cell Biology, PhD in Biomedical Sciences    UNT Health Science Center
Student Name Withheld  -  2008-08-21
Major Professor, GSBS Cell Biology, Doctor of Philosophy    UNT Health Science Center
Fuller,John A  -  2008-04-30
Dissertation Committee, GSBS Cell Biology and Genetics, Doctor of Philosophy    UNT Health Science Center
Fuller,John A  -  2008-04-30
Dissertation Committee, GSBS Cell Biology and Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Zode,Gulab S  -  2008-01-14
Dissertation Committee, GSBS Cell Biology and Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Zode,Gulab S  -  2008-01-14
Dissertation Committee, GSBS Cell Biology and Genetics, Doctor of Philosophy    UNT Health Science Center
Tovar-Vidales,Tara  -  2006-08-16
Dissertation Committee, GSBS Cell Biology and Genetics, Doctor of Philosophy    UNT Health Science Center
Tovar-Vidales,Tara  -  2006-08-16
Dissertation Committee, GSBS Cell Biology and Genetics, PhD in Biomedical Sciences    UNT Health Science Center
Mills,Christy Elizabeth  -  2006-06-01
Major Professor, GSBS Pharmacology & Neuroscience, Master of Science    UNT Health Science Center
 
Grants and Contracts   More...    Close... 
2016 Project RN7051: Novel Glaucoma Treatment Using Genome Editing (1 R01 EY024259-01)
CELL BIOLOGY & IMMUNOLOGYUniversity of Iowa
2015 Project RI6139: Assessment of Ocular Disease in the HABLE Cohort (IAADR)
CELL BIOLOGY & IMMUNOLOGYIntramural Research(UNTHSC)
2015 Project RN0068: Glucocorticoids, Ocular Hypertension, and Glaucoma (2 R21 EY016242-06A1)
CELL BIOLOGY & IMMUNOLOGYNEI: National Eye Institute
2015 Project RP0241: Test Three Nicox Compounds (n=3?) for Glucocorticoid Activity and Potential for Raising IOP Using In Vitro, Ex Vivo, and In Vivo Models ()
CELL BIOLOGY & IMMUNOLOGYNicox Research Institute
2015 Project RN0108: Conditionally Immortalized Mouse TM Cell and RGC Lines (1 R21 EY023364-01A1)
CELL BIOLOGY & IMMUNOLOGYNEI: National Eye Institute
2015 Project RP0214: ID1 Protein Prevents Deleterious Effect of TBF゚2 in Ocular Hypertension Model: Implication for Novel Glaucoma Therapy (For: Avani Mody) (G20141015669897)
CELL BIOLOGY & IMMUNOLOGYSigma Xi
2014 Project RP0162: Assessment of Efficacy of Reata Compound in Retinal Oxidative Injury Models ()
CELL BIOLOGY & IMMUNOLOGYReata Pharmaceuticals, Inc.
2014 Project RI6079: Assessment of Changes in the Visual Centers of the Brain in Acute Mouse Models of Retina Injury: The Role of Electrocardiographic and Echocardiographic Screening with TCOM Student Neal Olarte (TCOM-Smith-Barbaro)
CELL BIOLOGY & IMMUNOLOGYIntramural Research(UNTHSC)
2014 Project RN7045: MicroRNA-Directed Modulation of Intraocular Pressure (203-2853 (EY023287))
CELL BIOLOGY & IMMUNOLOGYDuke University
2013 Project RP0125: Retina Ganglion Cell Subtype Specific Cell Death in a Mouse Model of Human Primary Open Angle Glaucoma (for Colleen McDowell) ()
CELL BIOLOGY & ANATOMYGlaucoma Research Foundation
2012 Project RP0097: Complement Expression Patterns in the Retina and Superior Colliculus of Mice in a Novel Pressure Dependent Model of Glaucoma - Graduate Student, Sean Silverman (G20120315160682)
CELL BIOLOGY & ANATOMYSigma Xi
2012 Project RP0096: Evaluation of SFRP1 and TGFB Signaling Pathways in Glaucoma ()
CELL BIOLOGY & ANATOMYAlcon Research Limited
2012 Project RP0081: Research Program to Determine the Effect of Donor Eye Time to Preservation on Ocular Tissue RNA Quality and on Overall Ocular Morphology ()
CELL BIOLOGY & ANATOMYLions Eye Inst for Transplant & Research
2012 Project RP0104: UNTHSC Support for Lockheed Martin in the Area of Eye Safety Pertaining to Optical Radiation (PO4100455494)
CELL BIOLOGY & ANATOMYLockheed Martin Missiles & Fire Control
2011 Project RP0034: Role of TGFB2-induced OHT in Bovine Perfusion Organ Culture (RA-10-6027)
CELL BIOLOGY & ANATOMYAlcon Research Limited
2011 Project RN0038: A New Mouse Model of Human Primary Open-Angle Glaucoma (5 R21 EY019977-02)
CELL BIOLOGY & ANATOMYNEI: National Eye Institute
2011 Project RF0021: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Project 5 (W81XWH-10-2-0003)
CELL BIOLOGY & ANATOMYDepartment of the Army
2011 Project RF0022: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Project 6 (W81XWH-10-2-0003)
CELL BIOLOGY & ANATOMYDepartment of the Army
2009 Project G70442: Anecortave Acetate Mechanism of Action ()
CELL BIOLOGY & ANATOMYAlcon Research Limited
2015 Project RN0124: Non-Invasive Technique for In Vivo Detection of Retinal Reactive Oxygen Species (1 R21 EY024635-01)
PHARMACEUTICAL SCIENCESNEI: National Eye Institute
2015 Project RP0238: Targeting ASICs in Optic Neurodegenerative Diseases is Neuroprotective (G2015163)
PHARMACOLOGY & NEUROSCIENCEBrightFocus Foundation
2014 Project RN0014: Biology, Immunology & Therapy for Acanthamoeba Keratitis (2 R01 EY009756-12A2)
CELL BIOLOGY & IMMUNOLOGYNEI: National Eye Institute
2013 Project RN0069: Glucocorticoids, Ocular Hypertension, and Glaucoma (2 R01 EY016242-06A1)
PHARMACOLOGY & NEUROSCIENCENEI: National Eye Institute
2012 Project RI6032: Identification of Genes/Proteins Responsible for Glaucoma-Associated Cross-Linked Actin Network (CLAN) Formation in the Trabecular Meshwork ()
CELL BIOLOGY & ANATOMYIntramural Research(UNTHSC)
2011 Project RF0020: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Project 4 (W81XWH-10-2-0003)
CELL BIOLOGY & ANATOMYDepartment of the Army
2011 Project RF0018: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Project 2 (W81XWH-10-2-0003)
PHARMACOLOGY & NEUROSCIENCEDepartment of the Army
2011 Project RF0019: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Project 3 (W81XWH-10-2-0003)
CELL BIOLOGY & ANATOMYDepartment of the Army
2011 Project RF0017: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Project 1 (W81XWH-10-2-0003)
PHARMACOLOGY & NEUROSCIENCEDepartment of the Army
2011 Project RF0016: Vision Integrating Strategies in Opthalmology and Neurochemistry (VISION) - Core (W81XWH-10-2-0003)
PHARMACOLOGY & NEUROSCIENCEDepartment of the Army
2008 Project G71150: Glucocorticoids, Ocular Hypertension and Glaucoma (1 R01 EY016242-01A1)
PHARMACOLOGY & NEUROSCIENCENEI: National Eye Institute
 
Intellectual Property   More...    Close... 
Title:     
Inventors:     
Abstract:     
Department:    
Patent Status:    Date:    
Title:   RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma  
Inventors:   CLARK AF, Wang W-H, McNatt LG, Chatterton JE  
Abstract:     
Department:    
Patent Status:   Patent Granted Date:    
Title:   Bone morphogenetic proteins (BMP), BMP receptors and BMP binding proteins and their use in the diagnosis and treatment of glaucoma  
Inventors:   CLARK AF, Wordinger RJ  
Abstract:     
Department:    
Patent Status:   Patent Granted Date:    
Title:   Transferrin/transferrin receptor-mediated siRNA delivery  
Inventors:   Chatterton JE, CLARK AF  
Abstract:     
Department:    
Patent Status:   Patent Granted Date:    
Title:   Transferrin/trasferrin receptor mediated siRNA delivery  
Inventors:   Chatterton JE, Clark AF  
Abstract:     
Department:    
Patent Status:   Patent Granted Date:    
Title:   RNAi-mediated inhibition of TNFalpha signaling pathway for treatment of ocular hypertension  
Inventors:   Chatterton JE, Clark AF, Bingaman DP, Wax MB, Timmers AM  
Abstract:     
Department:    
Patent Status:   Patent Granted Date:    
 
Journals   More...    Close... 
McElnea EM, Hughes E, McGoldrick A, McCann A, Quill B, Docherty N, Irnaten M, Farrell M, CLARK AF, O達rien C, Wallace D.. Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells.. BMC Ophthalmology. 2015 August; 2: 14  Published
Ethier CR, Morrison JC, CLARK AF. Introduction to special issue on glaucomatous optic neuropathy. In vivo models and techniques.. Experimental Eye Research. 2015 August  Accepted/In-press
Choudhury S, Liu Y, CLARK AF, Pang, I-H. Caspase-7: a critical mediator of optic nerve injury induced retinal ganglion cell death.. Molecular Neurodegeneration. 2015 August; 10: 40  Published
Millar JC, Phan T, Pang I-H, CLARK AF.. Strain and age effects on aqueous humor dynamics in the mouse.. Invest. Ophthalmol. Vis.Sci.. 2015 August. (56): 5764-5776  Published
O達rien C, CLARK AF. Introduction to special issue on ocular fibrosis. Experimental Eye Research. 2015 August  Accepted/In-press
Pang I-H, Millar JC, CLARK AF.. Elevation of intraocular pressure using viral vectors targeting the trabecular meshwork.. Experimental Eye Research. 2015 August  Accepted/In-press
McDowell CM, Hernandez H, Mao W, CLARK AF. Gremlin induces ocular hypertension in mice through Smad3 dependent signaling. Invest. Ophthalmol. Vis.Sci.. 2015 August: 5485-5492  Published
Overby DR, CLARK AF. Animal models of glucocorticoid-induced glaucoma. Experimental Eye Research. 2015 July  Accepted/In-press
Peters JC, Bhattacharya S, CLARK AF, Zode GS.. Increased endoplasmic stress in human glaucomatous trabecular meshwork cells and tissues.. Invest. Ophthalmol. Vis. Sci.. 2015 July: 3860-3868  Published
Liu X, Ward K, Xavier C, Jann J, CLARK AF, Pang I-H, Wu H. The novel triterpenoid RTA408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation. 2015 July  Submitted
Kim B-J, Silverman SM, Liu Y, Wordinger RJ, Pang I-H, CLARK AF. In vitro and in vivo protective effects of JNK inhibitors on retinal ganglion cells. Molecular Neurodegeneration. 2015 June  Submitted
Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, CLARK AF, O達rien CJ. Calcium channel blockade modulates the strain induced extracellular matrix gene response in lamina cribrosa cells.. Quill B, Irnaten M, Docherty NG, McElnea EM, Wallace DM, CLARK AF, O達rien CJ. 2015 January; 99: 1009-1014  Published
Sharma TP, Liu Y, Wordinger RJ, Pang I-H, CLARK AF. Neuritin1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush.. Cell Death & Disease. 2015 January; 6: e1661  Published
Nashine S, Kim B-J, CLARK AF, Pang I-H. Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury.. Invest. Ophthalmol. Vis.Sci.. 2014 November; 56: 221-231  Published
Mueller BH, Park Y, Ma H-Y, Dibas A, CLARK AF, Yorio T. Sigma-1 receptor stimulation protects retinal ganglion cells from ischemic-like insult through the activation of extracellular-signal-related kinases 1/2.. Experimental Eye Research. 2014 October; 128: 156-169  Published
CLARK AF. A useful mouse model of glucocorticoid-induced ocular hypertension. Invest Ophthalmol Vis Sci. 2014 July; 55: 4934  Published
Wordinger RJ, CLARK AF. Lysyl oxidases in the trabecular meshwork.. J Glaucoma. 2014 June; 23: S55-S58  Published
McDonnell F, McNally S, CLARK AF, O達rien C, Wallace D. Increased DNA methylation and decreased TGFイ1 promoter methylation in glaucomatous lamina cribrosa cells.. 2014 May  Submitted
Wordinger RJ, Tovar-Vidales T, CLARK AF. Identification and localization of lamina cribrosa cells in the human optic nerve head. 2014 May  Submitted
Sharma TP, McDowell CM, Liu Y, Wagner AH, Thole D, Faga B, Wordinger RJ, Braun TA, CLARK AF.. Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice.. Molecular Neurodegeneration. 2014 March; 9: 21  Published
Wordinger RJ, Sharma T, CLARK AF. The role of TGF-イ2 and bone morphogenetic proteins (BMPs) in the trabecular meshwork and glaucoma.. J. Ocular Pharm. Therap.. 2014 March; 30: 154-162  Published
Jain A, Wordinger RJ, Yorio T, CLARK AF. Role of the alternatively spliced glucocorticoid receptor isoform GRイ in steroid responsiveness and glaucoma. J. Ocular Pharm. Therap.. 2014 March; 30: 121-127  Published
Zode GS, Sharma AB, Lin X, Searby CC, Bugge K, Kim GH, CLARK AF, Sheffield VC.. Ocular-specific ER stress reduction rescues glaucoma in a murine model of glucocorticoid-induced glaucoma.. J. Clinical Investigation. 2014 February; 124: 1956-1965
Liu Y, McDowell CM, Zhang Z, Tebow HE, Wordinger RJ, CLARK AF. Monitoring retinal morphological and functional changes in mice following optic nerve crush.. Invest Ophthalmol Vis Sci. 2014 January; 55: 3766-3774  Published
Clark A, Tamm ER, Al-Ubaidi MR, Hollyfield JG. On the use of immortalized ocular cell lines in vision research: the unfortunate story of RGC-5. Exp Eye Research. 2013 November; 116: 433  Published
Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, CLARK AF, O'Brien CJ. Elevated maxi-K+ ion channel current in glaucomatous lamina cribrosa cells.. Exp Eye Research. 2013 November; 115: 224-229  Published
Wallace DM, CLARK AF, Lipson KE, Andrews D, Crean JK, O'Brien CJ. Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells.. Invest Ophthalmol Vis Sci. 2013 November; 54: 7836-7848  Published
Giovingo M, Nolan M, McCarty R Pang I-H, CLARK AF, Beverly R, Schwartz S, Stamer WD, Walker L, Grybauskas A, Skuran K, Kuprys P, Yue B, Knepper PA. sCD44 overexpression increases intraocular pressure and aqueous outflow resistance.. Molecular Vision. 2013 November; 19: 2151-2164  Published
McDowell C, Tebow H, Wordinger RJ, CLARK AF. Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice. Exp Eye Research. 2013 October; 116: 419-423  Published
Kim, BJ, Braun TA, Wordinger RJ, CLARK AF.. Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia/reperfusion injury in mice.. Molecular Neurodegeneration. 2013 September; 8: 21  Published
Krishnamoorthy R, CLARK AF, Daudt D, Vishwanatha JK, Yorio T. A Forensic Path to RGC-5 Cell Line Identification: Lessons Learned. Invest. Ophthalmol. Vis. Sci.. 2013 August; 54: 5712-5719  Published
Medina-Ortiz WE, Belmares R, Neubauer S, Wordinger RJ, CLARK AF. Cellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-beta2.. Invest Ophthalmol Vis Sci. 2013 August; 54: 6779-6788  Published
Tovar-Vidales T, Fitzgerald AM, CLARK AF, Wordinger RJ. Biologically active bone morphogenetic protein-1 in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.. 2013 July; 54: 4741-4748  Published
Wagner A, Anand NN, Wang W-H, Chatterton JE, Sun D, Shepard AR, Jacobson N, Pang I-H, DeLuca AP, Casavant TL, Sheetz TE, Mullins RF, Braun TA, CLARK AF. Exon level expression profiling of ocular tissues. Experimental Eye Research. 2013 June; 111: 105-111  Published
Kim B-J, Sprehe N, Morganti A, Wordinger RJ, CLARK AF. The effect of postmortem time on RNA quality of human ocular tissues. Molecular Vision. 2013 June; 19: 1290-1295  Published
Sethi A, Wordinger RJ, CLARK AF. Gremlin utilizes TGFイ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Experimental Eye Research. 2013 June; 113: 117-127  Published
Kim, BJ, Braun TA, Wordinger RJ, CLARK AF. Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia/reperfusion injury in mice. Molecular Neurodegeneration. 2013 June; 8: 21  Published
Jain A, Liu X, Wordinger RJ, Yorio T, Cheng Y-Q, CLARK AF. Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma. Invest. Ophthalmol. Vis. Sci.. 2013 May; 54: 3137-3142  Published
Mao W, Liu Y, Wordinger RJ, CLARK AF. A magnetic bead-based method for mouse trabecular meshwork cell isolation. Invest. Ophthalmol. Vis. Sci.. 2013 May; 54: 3600-3606  Published
Scheetz TE, Fingert JH, Wang K, Kuehn MH, Knudtson KL, Alward WLM, Boldt HC, Russell SR, Folk JC, Casavant TL, Braun TA, CLARK AF, Stone EM, Sheffield VC. A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel loci. PLoS One. 2013 March; 8: e58657  Published
Mueller BH, Park Y, Daudt DR, Ma H-Y, Akopova I, Stankowska D, CLARK AF, Yorio T. Sigma-1 receptor stimulation attenuates calcium influx through activated L-type voltage-gated calcium channels in primary retinal ganglion cells. Experimental Eye Research. 2013 February; 107: 21-31  Published
Mao W, Liu Y, Mody A, Montecchi-Palmer M, Wordinger RJ, CLARK AF. Characterization of a spontaneously immortalized bovine trabecular meshwork cell line. Experimental Eye Research. 2012 December; 105: 53-59  Published
Fitzgerald AM, Benz C, CLARK AF, Wordinger RJ. The effects of transforming growth factor-イ2 on the expression of follistatin and activin A in normal and glaucoma human trabecular meshwork cells and tissues. Invest. Ophthalmol. Vis. Sci.. 2012 October; 53: 7358-7369  Published
Mao W, Millar JC, Wang W-H, Silverman S, Liu Y, Wordinger RJ, Rubin J, Pang I-H, CLARK AF. Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest. Ophthalmol. Vis. Sci.. 2012 - ; 53: 7043-7051  Published
Bollinger KE, Crabb JS, Yuan X, Putliwala T, CLARK AF, Crabb JW. Proteomic similarities in steroid responsiveness in normal and glaucomatous trabecular meshwork cells. Molecular Vision. 2012 July; 18: 2001-2011  Published
McDowell C, Luan T, Zhang Z, Putliwala T, Millar JC, John SWM, Pang I-H, CLARK AF. Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice. Exp Eye Research. 2012 May; 100: 65-72  Published
Dibas A, Jiang M, Fudala, R, Gryczynski I, Gryczynski Z, CLARK AF, Yorio T. Fluorescent protein labeled glucocorticoid receptor isoform trafficking in cultured trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.. 2012 May; 53: 2938-2950  Published
CLARK AF. The cell and molecular biology of glaucoma: biomechanical factors in glaucoma. Invest. Ophthalmol. Vis. Sci.. 2012 May; 53: 2473-2475  Published
Fernandes FA, Harder JM, Fornarola LB, Freeman RS, CLARK AF, Pang I-H, John SW, Libby RT. JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death. Neurobiology of Disease. 2012 May; 46: 393-401  Published
Kirwan RP, Felice L, CLARK AF, O達rien CJ, Leonard MO. Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture. Invest. Ophthalmol. Vis. Sci.. 2012 April; 53: 2243-2255  Published
Mao W, Rubin JS, Anoruo N, Wordinger RJ, CLARK AF. SFRP1 promoter methylation and expression in human trabecular meshwork cells. Experimental Eye Research. 2012 April; 97: 130-136  Published
Howell GR, Sota I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll K, Barbay JM, Porciatti V, Anderson MG, Smith RS, CLARK AF, Libby RT, John SWM. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clinical Investigation. 2012 April; 122: 1246-1261  Published
Jain A, Wordinger RJ, Yorio T, CLARK AF. Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.. 2012 February; 53: 857-866  Published
Sethi A, Wordinger RJ, CLARK AF. Lysyl oxidase: focus on molecules. Experimental Eye Research. 2012 February; 104: 97-98  Published
Bollinger KE, Crabb JS, Yuan X, Putliwala T, CLARK AF, Crabb JW. Quantitative proteomics: TGFイ2 signaling in trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.. 2011 October; 52: 8287-8294  Published
Mao W, Tovar-Vidales T, Yorio T, Wordinger RJ, CLARK AF. Perfusion cultured bovine anterior segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension and glaucoma. Invest. Ophthalmol. Vis. Sci.. 2011 October; 52: 8068-8075  Published
O坦eilly S, Pollock N, Currie L, Paraoan L, AF CLARK, Grierson I. Inducers of cross-linked actin networks (CLANs) in trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.. 2011 September; 52: 7316-7324  Published
Zode GS, Sethi A, Brun-Zinkernagel A-M, Chang I-F, CLARK AF, Wordinger RJ. Transforming growth factor-イ2 increases extracellular matrix proteins in the optic nerve head cells via activation of Smad signaling pathway. Molecular Vision. 2011 September; 17: 1745-1758  Published
Zode GS, Keuhn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, CLARK AF, Stone EM, Sheffield VC. Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma. J Clinical Investigation. 2011 September; 121: 3542-3553  Published
Sethi A, Jain A, Zode GS, Wordinger RJ, Clark AF. Role of TGF{beta}/Smad Signaling in Gremlin Induction of Human Trabecular Meshwork Extracellular Matrix Proteins.. Investigative ophthalmology & visual science. 2011 August; 52. (8): 5251-9  Published
Sethi A, Mao W, Wordinger RJ, Clark AF. Transforming Growth Factor-{beta} Induces Extracellular Matrix Protein Cross-Linking Lysyl Oxidase (LOX) Genes in Human Trabecular Meshwork Cells.. Investigative ophthalmology & visual science. 2011 August; 52. (8): 5240-50  Published
Tovar-Vidales T, Clark AF, Wordinger RJ. Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells.. Experimental eye research. 2011 June 24  Published
Mao W, Wordinger RJ, Clark AF. Functional analysis of disease-associated polymorphism LRP5.Q89R.. Molecular vision. 2011 April 08; 17: 894-902  Published
Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.. The Journal of clinical investigation. 2011 April 01; 121. (4): 1429-44  Published
Browne JG, Ho SL, Kane R, Oliver N, Clark AF, O. Connective tissue growth factor is increased in pseudoexfoliation glaucoma.. Investigative ophthalmology & visual science. 2011; 52. (6): 3660-6  Published
Quill B, Docherty NG, Clark AF, O. The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells.. Investigative ophthalmology & visual science. 2011 March; 52. (3): 1908-15  Published
Millar JC, Clark AF, Pang IH. Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion.. Investigative ophthalmology & visual science. 2011 February; 52. (2): 685-94  Published
Job R, Raja V, Grierson I, Currie L, O. Cross-linked actin networks (CLANs) are present in lamina cribrosa cells.. The British journal of ophthalmology. 2010 October; 94. (10): 1388-92  Published
Wang Z, Do CW, Valiunas V, Leung CT, Cheng AKW, CLARK AF, Wax MD, Chatterton JE, Civan MM. Regulation of gap-junction coupling in bovine ciliary epithelium. Am. J. Physiol. Cell. Physiol. 2010; 298: C798-C806  Published
Scheetz TE, Fingert JH, Wang K, Kuehn M, Braun TA, Grundstad AJ, Beck J, Knudtson K, Casavant TL, Alward WL, Folk J, CLARK AF, Stone EM, Sheffield VC. Genome-wide association study of glaucoma reveals disease complexity. 2010  Submitted
Y, Cracknell KRB, O坦eily S, Brotchie D, Hoare M-J, CLARK AF, Grierson I. Biomechanical properties of polygonal actin network arrangements in trabecular meshwork cells. 2010  Submitted
Irnaten M, Barry RC, Wallace D, Duff AA, Docherty N, Quill B, CLARK AF, O達rien CJ. Abnormal calcium homeostasis in glaucomatous lamina cribrosa cells. 2010  Submitted
Davis RL, Kahraman M, Prins TJ, Beaver Y, Cook TG, Cramp J, Cayanan CS, Gardiner EM, McLaughlin MA, Clark AF, Hellberg MR, Shiau AK, Noble SA, Borchardt AJ. Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma.. Bioorganic & medicinal chemistry letters. 2010 June 01; 20. (11): 3361-6  Published
Mao W, Wordinger RJ, Clark AF. Focus on molecules: SFRP1.. Experimental eye research. 2010 May 15  Published
Fingert JH, Alward WL, Wang K, Yorio T, Clark AF. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.. Molecular vision. 2010 April 03; 16: 596-601  Published
Shepard AR, Millar JC, Pang IH, Jacobson N, Wang WH, Clark AF. Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes.. Investigative ophthalmology & visual science. 2010 April; 51. (4): 2067-76  Published
Kirwan RP, Wordinger RJ, CLARK AF, O達rien CJ.. Differential global and extracellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells.. Molecular Vision. 2009; 15: 76-88  Published
Hoare M-J, Grierson I, Brotchie D, Pollock N, Cracknell K, CLARK AF.. Cross-linked actin networks (CLANs) in the trabecular meshwork of the normal and glaucoma human eye in situ.. Investigative ophthalmology and visual science. 2009; 50. (3): 1255-1263  Published
Irnaten M, Barry RC, Quill B, CLARK AF, Harvey BJ, O達rien CJ.. Activation of stretch-activated cannels and maxi K+ channels by membrane stress of human lamina cribrosa cells.. Investigative opthalmology and visual science. 2009; 50. (1): 194-202  Published
Robin AL, CLARK AF, Covert D, Krueger S, Bergamini MV, Landry TA, Dickerson JE, Scheib SA, Realini T, DeFaller JM, Cagle GD.. Anterior juxtascleral delivery of anecortave acetate in eyes with primary open-angle glaucoma: a pilot study.. American Journal of Ophthalmology. 2009; 147. (1): 45-50  Published
Zode GS, CLARK AF, Wordinger RJ.. Bone morphogenic protein 4 inhibits TGF-b2 stimulation of extracellular matrix proteins in human optic nerve head cells: role of gremlin in ECM modulation. Glia. 2009; 57. (7): 755-766  Published
CLARK AF, Wordinger RJ. The role of steroids in outflow resistance. Experimental Eye Research. 2009; 88. (4): 752-759  Published
Fuller JA, Brun-Zinkernagel A-M, CLARK AF, Wordinger RJ.. Sutilisn-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head. Investigative opthalmology and visual science. 2009; EPub ahead of print  Published
Wade NC, Grierson I, O'Reilly S, Hoare MJ, Cracknell KP, Paraoan LI, Brotchie D, Clark AF. Cross-Linked Actin Networks (CLANs) in Bovine Trabecular Meshwork Cells. Experimental Eye Research. 2009; EPub ahead of print  Published
Wordinger RJ, CLARK AF. Growth factors and neurotrophic factors as targets. Thomas Yorio, Abbot F. Clark, Martin Wax. Ocular Therapeutics: Eye on New Discoveries. 2008: 87-116  Published
Millar JC, Pang I-H, Wang W-H, Wang Y, Davidson BL, CLARK AF. Effect of immunomodulation with anti-CD40L antibody on adenoviral-mediated transgene expression in mouse anterior segment. Molecular Vision. 2008; 14: 10-19  Published
Zhang X, CLARK AF, Yorio T. FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness. Invest. Ophthalmol. Vis. Sci.. 2008; 49: 1037-1047  Published
Pang I-H, Wang W-H, Millar JC, CLARK AF. Intraocular pressure measurement in rodents. Chin J Ophthalmo. 2008; 44: 465-468  Published
Wang WH, McNatt LG, Pang IH, Hellberg PE, Fingert JH, McCartney MD, Clark AF. . Increased expression of serum amyloid A in glaucoma and its effect on intraocular pressure.. Investigative ophthalmology & visual science. 2008 May; 49. (5): 1916-23  Published
Zhang X, Clark AF, Yorio T. . FK506-binding protein 51 regulates nuclear transport of the glucocorticoid receptor beta and glucocorticoid responsiveness.. Investigative ophthalmology & visual science. 2008 March; 49. (3): 1037-47  Published
Wang WH, McNatt LG, Pang IH, Millar JC, Hellberg PE, Hellberg MH, Steely HT, Rubin JS, Fingert JH, Sheffield VC, Stone EM, Clark AF. . Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure.. The Journal of clinical investigation. 2008 March; 118. (3): 1056-64  Published
Tovar-Vidales T, Roque R, Clark AF, Wordinger RJ. . Tissue transglutaminase expression and activity in normal and glaucomatous human trabecular meshwork cells and tissues.. Investigative ophthalmology & visual science. 2008 February; 49. (2): 622-8  Published
Wordinger RJ, Zode G, Clark AF. . Focus on Molecules: Gremlin.. Experimental eye research. 2007 December 04  Published
O'Leary BM, Davis SG, Smith MF, Brown B, Kemp MB, Almabrazi H, Grundstad JA, Burns T, Leontiev V, Andorf J, Clark AF, Sheffield VC, Casavant TL, Scheetz TE, Stone EM, Braun TA. . Transcript annotation prioritization and screening system (TrAPSS) for mutation screening.. Journal of bioinformatics and computational biology. 2007 December; 5. (6): 1155-72  Published
Zode GS, Clark AF, Wordinger RJ. . Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells.. Investigative ophthalmology & visual science. 2007 November; 48. (11): 5058-67  Published
Wordinger RJ, Clark AF. . Bone morphogenetic proteins and their receptors in the eye.. Experimental biology and medicine (Maywood, N.J.). 2007 September; 232. (8): 979-92  Published
Pang IH, Clark AF. . Rodent models for glaucoma retinopathy and optic neuropathy.. Journal of glaucoma. 2007 August; 16. (5): 483-505  Published
Yuan C, Zins EJ, CLARK AF, Huang AJW. Supression of keratoepithelin and myocilin by small interfering RNAs (siRNA) in vitro. Molecular Vision. 2007: 2083-2095  Published
Pang I-H, Zeng H, Fleenor DL, CLARK AF. Pigment epithelium-derived factor protects retinal ganglion cells. BMC Neuroscience. 2007; 8: 11  Published
Liu X, CLARK AF, Wordinger RJ. Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head. Molecular Vision. 2007; 13: 758-763  Published
Agarwal N, Agarwal R, Kumar DM, Ondricek A, CLARK AF, Wordinger RJ, Pang I-H. Comparison of expression profile of neurotrophins and their receptors in primary and transformed rat retinal ganglion cells. Molecular Vision. 2007; 13: 1311-1318  Published
Libby RT, Howell GR, Pang I-H, Savinova OV, Mehalow A, Barter J, Smith RS, CLARK AF, John SWM. Inducible nitric oxide synthase, Nos2, is not necessary to mediate inherited glaucoma. BMC Genetics. 2007; 8: 108  Published
Shepard AR, Jacobson N, Millar JC, Pang IH, Steely HT, Searby CC, Sheffield VC, Stone EM, Clark AF. . Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.. Human molecular genetics. 2007 March 15; 16. (6): 609-17  Published
Wordinger RJ, Fleenor DL, Hellberg PE, Pang IH, Tovar TO, Zode GS, Fuller JA, Clark AF. . Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.. Investigative ophthalmology & visual science. 2007 March; 48. (3): 1191-200  Published
Zhang X, Ognibene CM, Clark AF, Yorio T. . Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor beta.. Experimental eye research. 2007 February; 84. (2): 275-84  Published
Mullins RF, Olvera MA, Clark AF, Stone EM. . Fibulin-5 distribution in human eyes: relevance to age-related macular degeneration.. Experimental eye research. 2007 February; 84. (2): 378-80  Published
Clark AF. . Preclinical efficacy of anecortave acetate.. Survey of ophthalmology. 2007 January; 52 Suppl 1: S41-8  Published
Clark AF. . Mechanism of action of the angiostatic cortisene anecortave acetate.. Survey of ophthalmology. 2007 January; 52 Suppl 1: S26-34  Published
Kim CY, Kwon YH, CLARK AF, Kuehn MH. Gene expression profile of the human retinal ganglion cell layer. Molecular Vision. 2006; 12: 1640-1648  Published
Steely HT, Dillow GW, Bian L, Grundstad J, Braun TA, Casavant TL, McCartney MD, CLARK AF. Protein expression in a transformed trabecular meshwork cell line: proteome analysis. Mol. Vis.. 2006; 12: 373-383  Published
McCartney MD, Cantu-Crouch D, Clark AF. . Freeze-fracture examination of cultured human trabecular meshwork cells: effect of dexamethasone.. Experimental eye research. 2006 June; 82. (6): 994-1001  Published
Zhang X, Clark AF, Yorio T. . Heat shock protein 90 is an essential molecular chaperone for nuclear transport of glucocorticoid receptor beta.. Investigative ophthalmology & visual science. 2006 February; 47. (2): 700-8  Published
Chauhan BC, Levatte TL, Garnier KL, Tremblay F, Pang IH, Clark AF, Archibald ML. . Semiquantitative optic nerve grading scheme for determining axonal loss in experimental optic neuropathy.. Investigative ophthalmology & visual science. 2006 February; 47. (2): 634-40  Published
Braun TA, Shankar SP, Davis S, O'Leary B, Scheetz TE, Clark AF, Sheffield VC, Casavant TL, Stone EM. . Prioritizing regions of candidate genes for efficient mutation screening.. Human mutation. 2006 February; 27. (2): 195-200  Published
Fleenor DL, Shepard AR, Hellberg PE, Jacobson N, Pang IH, Clark AF. . TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure.. Investigative ophthalmology & visual science. 2006 January; 47. (1): 226-34  Published
Wang WH, Millar JC, Pang IH, Wax MB, Clark AF. . Noninvasive measurement of rodent intraocular pressure with a rebound tonometer.. Investigative ophthalmology & visual science. 2005 December; 46. (12): 4617-21  Published
Zhang X, Clark AF, Yorio T. . Regulation of glucocorticoid responsiveness in glaucomatous trabecular meshwork cells by glucocorticoid receptor-beta.. Investigative ophthalmology & visual science. 2005 December; 46. (12): 4607-16  Published
Kirwan RP, Leonard MO, Murphy M, Clark AF, O'Brien CJ. . Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells.. Glia. 2005 December; 52. (4): 309-24  Published
Libby RT, Anderson MG, Pang IH, Robinson ZH, Savinova OV, Cosma IM, Snow A, Wilson LA, Smith RS, Clark AF, John SW. . Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.. Visual neuroscience. 2005 September - June; 22. (5): 637-48  Published
Shepard AR, Jacobson N, Clark AF. . Importance of quantitative PCR primer location for short interfering RNA efficacy determination.. Analytical biochemistry. 2005 September 15; 344. (2): 287-8  Published
Pang IH, Wang WH, Millar JC, Clark AF. . Measurement of mouse intraocular pressure with the Tono-Pen.. Experimental eye research. 2005 September; 81. (3): 359-60  Published
Pang IH, Johnson EC, Jia L, Cepurna WO, Shepard AR, Hellberg MR, Clark AF, Morrison JC. . Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage.. Investigative ophthalmology & visual science. 2005 April; 46. (4): 1313-21  Published
Pang IH, Wang WH, Clark AF. . Acute effects of glaucoma medications on rat intraocular pressure.. Experimental eye research. 2005 February; 80. (2): 207-14  Published
Clark AF, Brotchie D, Read AT, Hellberg P, English-Wright S, Pang IH, Ethier CR, Grierson I. . Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue.. Cell motility and the cytoskeleton. 2005 February; 60. (2): 83-95  Published
Choi J, Miller AM, Nolan MJ, Yue BY, Thotz ST, Clark AF, Agarwal N, Knepper PA. . Soluble CD44 is cytotoxic to trabecular meshwork and retinal ganglion cells in vitro.. Investigative ophthalmology & visual science. 2005 January; 46. (1): 214-22  Published
Lambert WS, Clark AF, Wordinger RJ. . Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation.. BMC neuroscience. 2004 December 03; 5. (1): 51  Published
Pang IH, Li B, Clark AF. . [The strategies for optic never protection in glaucoma patients]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 2004 November; 40. (11): 783-7  Published
Kirwan RP, Crean JK, Fenerty CH, Clark AF, O'Brien CJ. . Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head.. Journal of glaucoma. 2004 August; 13. (4): 327-34  Published
Pang IH, Li B, Clark AF. . [The pathogenesis of retinal ganglia cell apoptosis induced by glaucoma]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 2004 July; 40. (7): 495-9  Published
Lambert WS, Clark AF, Wordinger RJ. . Effect of exogenous neurotrophins on Trk receptor phosphorylation, cell proliferation, and neurotrophin secretion by cells isolated from the human lamina cribrosa.. Molecular vision. 2004 April 19; 10: 289-96  Published
Zhang X, Clark AF, Yorio T. . Interactions of endothelin-1 with dexamethasone in primary cultured human trabecular meshwork cells.. Investigative ophthalmology & visual science. 2003 December; 44. (12): 5301-8  Published
Agapova OA, Yang P, Wang WH, Lane DA, Clark AF, Weinstein BI, Hernandez MR. . Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.. Neurobiology of disease. 2003 October; 14. (1): 63-73  Published
Pang IH, Fleenor DL, Hellberg PE, Stropki K, McCartney MD, Clark AF. . Aqueous outflow-enhancing effect of tert-butylhydroquinone: involvement of AP-1 activation and MMP-3 expression.. Investigative ophthalmology & visual science. 2003 August; 44. (8): 3502-10  Published
Fleenor DL, Pang IH, Clark AF. . Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells.. Investigative ophthalmology & visual science. 2003 August; 44. (8): 3494-501  Published
Pang IH, Hellberg PE, Fleenor DL, Jacobson N, Clark AF. . Expression of matrix metalloproteinases and their inhibitors in human trabecular meshwork cells.. Investigative ophthalmology & visual science. 2003 August; 44. (8): 3485-93  Published
Wordinger RJ, Lambert W, Agarwal R, Liu X, Clark AF. . Cells of the human optic nerve head express glial cell line-derived neurotrophic factor (GDNF) and the GDNF receptor complex.. Molecular vision. 2003 June 16; 9: 249-56  Published
Clark AF, Yorio T. . Ophthalmic drug discovery.. Nature reviews. Drug discovery. 2003 June; 2. (6): 448-59  Published
Chiu SK, Collier CP, Clark AF, Wynn-Edwards KE. . Salivary cortisol on ROCHE Elecsys immunoassay system: pilot biological variation studies.. Clinical biochemistry. 2003 May; 36. (3): 211-4  Published
Shepard AR, Jacobson N, Sui R, Steely HT, Lotery AJ, Stone EM, Clark AF. . Characterization of rabbit myocilin: Implications for human myocilin glycosylation and signal peptide usage.. BMC genetics. 2003 April 02; 4: 5  Published
Prasanna G, Krishnamoorthy R, Clark AF, Wordinger RJ, Yorio T. . Human optic nerve head astrocytes as a target for endothelin-1.. Investigative ophthalmology & visual science. 2002 August; 43. (8): 2704-13  Published
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF. . Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues.. Molecular vision. 2002 July 15; 8: 241-50  Published
Clark AF, Pang IH. . Advances in glaucoma therapeutics.. Expert opinion on emerging drugs. 2002 May; 7. (1): 141-63  Published
Pang IH, Moll H, McLaughlin MA, Knepper PA, De Santis L, Epstein DL, Clark AF. . Ocular hypotensive and aqueous outflow-enhancing effects of AL-3037A (sodium ferri ethylenediaminetetraacetate).. Experimental eye research. 2001 December; 73. (6): 815-25  Published
Shepard AR, Jacobson N, Fingert JH, Stone EM, Sheffield VC, Clark AF. . Delayed secondary glucocorticoid responsiveness of MYOC in human trabecular meshwork cells.. Investigative ophthalmology & visual science. 2001 December; 42. (13): 3173-81  Published
Lambert W, Agarwal R, Howe W, Clark AF, Wordinger RJ. . Neurotrophin and neurotrophin receptor expression by cells of the human lamina cribrosa.. Investigative ophthalmology & visual science. 2001 September; 42. (10): 2315-23  Published
Clark AF, Steely HT, Dickerson JE, English-Wright S, Stropki K, McCartney MD, Jacobson N, Shepard AR, Clark JI, Matsushima H, Peskind ER, Leverenz JB, Wilkinson CW, Swiderski RE, Fingert JH, Sheffield VC, Stone EM. . Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues.. Investigative ophthalmology & visual science. 2001 July; 42. (8): 1769-80  Published
Liu X, Lambert W, Agarwal R, Talati M, Cross W, Clark AF, Wordinger RJ. . Human trabecular meshwork cells express the ciliary neurotrophic factor (cntf) tripartite receptor complex.. Experimental eye research. 2001 June; 72. (6): 711-7  Published
Clark AF, Kawase K, English-Wright S, Lane D, Steely HT, Yamamoto T, Kitazawa Y, Kwon YH, Fingert JH, Swiderski RE, Mullins RF, Hageman GS, Alward WL, Sheffield VC, Stone EM. . Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head.. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2001 May; 15. (7): 1251-3  Published
Wang WH, McNatt LG, Shepard AR, Jacobson N, Nishimura DY, Stone EM, Sheffield VC, Clark AF. . Optimal procedure for extracting RNA from human ocular tissues and expression profiling of the congenital glaucoma gene FOXC1 using quantitative RT-PCR.. Molecular vision. 2001 April 17; 7: 89-94  Published
Krishnamoorthy RR, Agarwal P, Prasanna G, Vopat K, Lambert W, Sheedlo HJ, Pang IH, Shade D, Wordinger RJ, Yorio T, Clark AF, Agarwal N. . Characterization of a transformed rat retinal ganglion cell line.. Brain research. Molecular brain research. 2001 January 31; 86. (1-2): 1-12  Published
Jacobson N, Andrews M, Shepard AR, Nishimura D, Searby C, Fingert JH, Hageman G, Mullins R, Davidson BL, Kwon YH, Alward WL, Stone EM, Clark AF, Sheffield VC. . Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.. Human molecular genetics. 2001 January 15; 10. (2): 117-25  Published
Penn JS, Rajaratnam VS, Collier RJ, Clark AF. . The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity.. Investigative ophthalmology & visual science. 2001 January; 42. (1): 283-90  Published
Fingert JH, Clark AF, Craig JE, Alward WL, Snibson GR, McLaughlin M, Tuttle L, Mackey DA, Sheffield VC, Stone EM. . Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension.. Investigative ophthalmology & visual science. 2001 January; 42. (1): 145-52  Published
Pang IH, McCartney MD, Steely HT, Clark AF. . Human ocular perfusion organ culture: a versatile ex vivo model for glaucoma research.. Journal of glaucoma. 2000 December; 9. (6): 468-79  Published
Wordinger RJ, Lambert W, Agarwal R, Talati M, Clark AF. . Human trabecular meshwork cells secrete neurotrophins and express neurotrophin receptors (Trk).. Investigative ophthalmology & visual science. 2000 November; 41. (12): 3833-41  Published
Swiderski RE, Ross JL, Fingert JH, Clark AF, Alward WL, Stone EM, Sheffield VC. . Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization.. Investigative ophthalmology & visual science. 2000 October; 41. (11): 3420-8  Published
Steely HT, Clark AF. . The use of proteomics in ophthalmic research.. Pharmacogenomics. 2000 August; 1. (3): 267-80  Published
Steely HT, English-Wright SL, Clark AF. . The similarity of protein expression in trabecular meshwork and lamina cribrosa: implications for glaucoma.. Experimental eye research. 2000 January; 70. (1): 17-30  Published
Ke TL, Clark AF, Gracy RW. . Age-related permeability changes in rabbit corneas.. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 1999 December; 15. (6): 513-23  Published
Job R, Raja V, Grierson I, Currie L, O. Cross-linked actin networks (CLANs) are present in lamina cribrosa cells. Br. J. Ophthalmology. 1999; 94: 1388-1392  Published
McNatt LG, Weimer L, Yanni J, Clark AF. . Angiostatic activity of steroids in the chick embryo CAM and rabbit cornea models of neovascularization.. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 1999 October; 15. (5): 413-23  Published
Wordinger RJ, Clark AF. . Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma.. Progress in retinal and eye research. 1999 September; 18. (5): 629-67  Published
Clark AF, Mellon J, Li XY, Ma D, Leher H, Apte R, Alizadeh H, Hegde S, McLenaghan A, Mayhew E, D'Orazio TJ, Niederkorn JY. . Inhibition of intraocular tumor growth by topical application of the angiostatic steroid anecortave acetate.. Investigative ophthalmology & visual science. 1999 August; 40. (9): 2158-62  Published
Agarwal R, Talati M, Lambert W, Clark AF, Wilson SE, Agarwal N, Wordinger RJ. . Fas-activated apoptosis and apoptosis mediators in human trabecular meshwork cells.. Experimental eye research. 1999 May; 68. (5): 583-90  Published
Woo YM, Jardine AG, Clark AF, MacGregor MS, Bowman AW, Macpherson SG, Briggs JD, Junor BJ, McMillan MA, Rodger RS. . Early graft function and patient survival following cadaveric renal transplantation.. Kidney international. 1999 February; 55. (2): 692-9  Published
Wordinger RJ, Clark AF, Agarwal R, Lambert W, Wilson SE. . Expression of alternatively spliced growth factor receptor isoforms in the human trabecular meshwork.. Investigative ophthalmology & visual science. 1999 January; 40. (1): 242-7  Published
Clark AF. . New discoveries on the roles of matrix metalloproteinases in ocular cell biology and pathology.. Investigative ophthalmology & visual science. 1998 December; 39. (13): 2514-6  Published
Clark AF, Lewis SW. . Treatment of schizophrenia in childhood and adolescence.. Journal of child psychology and psychiatry, and allied disciplines. 1998 November; 39. (8): 1071-81  Published
Wordinger RJ, Clark AF, Agarwal R, Lambert W, McNatt L, Wilson SE, Qu Z, Fung BK. . Cultured human trabecular meshwork cells express functional growth factor receptors.. Investigative ophthalmology & visual science. 1998 August; 39. (9): 1575-89  Published
Dickerson JE, Steely HT, English-Wright SL, Clark AF. . The effect of dexamethasone on integrin and laminin expression in cultured human trabecular meshwork cells.. Experimental eye research. 1998 June; 66. (6): 731-8  Published
Clark AF. . AL-3789: a novel ophthalmic angiostatic steroid.. Expert opinion on investigational drugs. 1997 December; 6. (12): 1867-77  Published
Dickerson JE, Dotzel E, Clark AF. . Steroid-induced cataract: new perspective from in vitro and lens culture studies.. Experimental eye research. 1997 October; 65. (4): 507-16  Published
BenEzra D, Griffin BW, Maftzir G, Sharif NA, Clark AF. . Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization.. Investigative ophthalmology & visual science. 1997 September; 38. (10): 1954-62  Published
Gabelt BT, Wiederholt M, Clark AF, Kaufman PL. . Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport.. Investigative ophthalmology & visual science. 1997 August; 38. (9): 1700-7  Published
Clark AF, Sharp MG, Morley SD, Fleming S, Peters J, Mullins JJ. . Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology.. The Journal of biological chemistry. 1997 July 18; 272. (29): 18185-90  Published
Fleury M, Clark AF. . Sampling concerns in scanline algorithms.. IEEE transactions on medical imaging. 1997 June; 16. (3): 349-61  Published
Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, Sunden SL, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC. . Identification of a gene that causes primary open angle glaucoma.. Science (New York, N.Y.). 1997 January 31; 275. (5300): 668-70  Published
Sharp MG, Fettes D, Brooker G, Clark AF, Peters J, Fleming S, Mullins JJ. . Targeted inactivation of the Ren-2 gene in mice.. Hypertension. 1996 December; 28. (6): 1126-31  Published
Clark AF, Sharp MG, Mullins JJ. . Gene targeting and its application to basic hypertension research.. Clinical science (London, England : 1979). 1996 June; 90. (6): 435-46  Published
Clark AF, Lane D, Wilson K, Miggans ST, McCartney MD. . Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol.. Investigative ophthalmology & visual science. 1996 April; 37. (5): 805-13  Published
Shade DL, Clark AF, Pang IH. . Effects of muscarinic agents on cultured human trabecular meshwork cells.. Experimental eye research. 1996 March; 62. (3): 201-10  Published
Clark AF, Wilson K, de Kater AW, Allingham RR, McCartney MD. . Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes.. Investigative ophthalmology & visual science. 1995 February; 36. (2): 478-89  Published
Clark AF. . Prescribing practices in Britain.. Journal of the American Academy of Child and Adolescent Psychiatry. 1995 January; 34. (1): 1; author reply 2  Published
Early EA, Steiner RL, Clark AF, Char K. . Evidence for parallel junctions within high-Tc grain-boundary junctions.. Physical review. B, Condensed matter. 1994 October 01; 50. (13): 9409-9418  Published
Lepple-Wienhues A, Rauch R, Clark AF, Gr テ。ssmann A, Berweck S, Wiederholt M. . Electrophysiological properties of cultured human trabecular meshwork cells.. Experimental eye research. 1994 September; 59. (3): 305-11  Published
Clark AF, Wilson K, McCartney MD, Miggans ST, Kunkle M, Howe W. . Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells.. Investigative ophthalmology & visual science. 1994 January; 35. (1): 281-94  Published
Pang IH, Shade DL, Clark AF, Steely HT, DeSantis L. . Preliminary characterization of a transformed cell strain derived from human trabecular meshwork.. Current eye research. 1994 January; 13. (1): 51-63  Published
Wilson K, McCartney MD, Miggans ST, Clark AF. . Dexamethasone induced ultrastructural changes in cultured human trabecular meshwork cells.. Current eye research. 1993 September; 12. (9): 783-93  Published
McNatt LG, Lane D, Clark AF. . Angiostatic activity and metabolism of cortisol in the chorioallantoic membrane (CAM) of the chick embryo.. The Journal of steroid biochemistry and molecular biology. 1992 August; 42. (7): 687-93  Published
Steely HT, Browder SL, Julian MB, Miggans ST, Wilson KL, Clark AF. . The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells.. Investigative ophthalmology & visual science. 1992 June; 33. (7): 2242-50  Published
Orlowski J, Clark AF. . Epithelial-stromal interactions in the regulation of rat ventral prostate function: identification and characterization of pathways for androgen metabolism in isolated cell types.. Endocrinology. 1991 February; 128. (2): 872-84  Published
Clark AF, Tayler PJ, Bhate SR. . Nocturnal faecal soiling and anal masturbation.. Archives of disease in childhood. 1990 December; 65. (12): 1367-8  Published
Orlowski J, Clark AF. . Differential androgen modulation of acid phosphatase isozymes in primary cultures of rat ventral prostate epithelial and stromal cells.. Endocrinology. 1990 October; 127. (4): 2009-16  Published
Mizuno K, Clark AF, Streilein JW. . Anterior chamber-associated immune deviation induced by soluble antigens.. Investigative ophthalmology & visual science. 1989 June; 30. (6): 1112-9  Published
Mizuno K, Clark AF, Streilein JW. . Ocular injection of retinal S antigen: suppression of autoimmune uveitis.. Investigative ophthalmology & visual science. 1989 April; 30. (4): 772-4  Published
Mizuno K, Altman NF, Clark AF, Streilein JW. . Histopathologic analysis of experimental autoimmune uveitis attenuated by intracameral injection of S-antigen.. Current eye research. 1989 January; 8. (1): 113-21  Published
Mizuno K, Clark AF, Streilein JW. . Induction of anterior chamber associated immune deviation in rats receiving intracameral injections of retinal S antigen.. Current eye research. 1988 June; 7. (6): 627-32  Published
Orlowski J, Clark AF. . Estrogen metabolism by primary cultures of rat ventral prostate epithelial and stromal cells.. Journal of steroid biochemistry. 1988 March; 29. (3): 361-8  Published
Orlowski J, Bird CE, Clark AF. . Androgen metabolism and regulation of rat ventral prostate growth and acid phosphatase during sexual maturation.. The Journal of endocrinology. 1988 January; 116. (1): 81-90  Published
Moreland J, Ekin JW, Goodrich LF, Capobianco TE, Clark AF, Kwo J, Hong M, Liou SH. . Break-junction tunneling measurements of the high-Tc superconductor Y1Ba2Cu3O9- delta.. Physical review. B, Condensed matter. 1987 June 01; 35. (16): 8856-8857  Published
Moreland J, Clark AF, Goodrich LF, Ku HC, Shelton RN. . Tunneling spectroscopy of a La-Sr-Cu-O break junction: Evidence for strong-coupling superconductivity.. Physical review. B, Condensed matter. 1987 June 01; 35. (16): 8711-8713  Published
Clark AF, Davison K. . Mania following head injury. A report of two cases and a review of the literature.. The British journal of psychiatry : the journal of mental science. 1987 June; 150: 841-4  Published
Clark AF, Holden NL. . The persistence of prescribing habits: a survey and follow-up of prescribing to chronic hospital in-patients.. The British journal of psychiatry : the journal of mental science. 1987 January; 150: 88-91  Published
Clark AF, Wildenthal K. . Disproportionate reduction of actin synthesis in hearts of starved rats.. The Journal of biological chemistry. 1986 October 05; 261. (28): 13168-72  Published
Cromar MW, Clark AF, Fickett FR. . Flux limit of cosmic-ray magnetic monopoles from a multiply discriminating superconducting detector.. Physical review letters. 1986 June 16; 56. (24): 2561-2563  Published
Orlowski J, Clark AF. . Androgen metabolism and actions in rat ventral prostate epithelial and stromal cell cultures.. Biochemistry and cell biology = Biochimie et biologie cellulaire. 1986 June; 64. (6): 583-93  Published
Clark AF, DeMartino GN, Wildenthal K. . Effects of glucocorticoid treatment on cardiac protein synthesis and degradation.. The American journal of physiology. 1986 June; 250. (6 Pt 1): C821-7  Published
Clark AF, DeMartino GN, Croall DE. . Fractionation and quantification of calcium-dependent proteinase activity from small tissue samples.. The Biochemical journal. 1986 April 01; 235. (1): 279-82  Published
Ryan ED, Clark AF, Mobbs BG, Ooi TC, Sutherland DJ, Tustanoff ER. . Inter-laboratory quality control of estrogen and progesterone receptor assays in breast cancer tissue using lyophilised cytosols.. Clinical biochemistry. 1985 February; 18. (1): 20-6  Published
Reinlib LJ, Clark AF, Carafoli E. . A protein activator of the plasma membrane Ca++-ATPase of heart sarcolemma.. Journal of bioenergetics and biomembranes. 1984 December; 16. (5-6): 611-22  Published
Orlowski J, Bird CE, Clark AF. . Androgen 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in ventral prostate epithelial and stromal cells from immature and mature rats.. The Journal of endocrinology. 1983 October; 99. (1): 131-9  Published
Downey J, Mahan D, Flynn TG, Bird CE, Clark AF. . Rat prostatic acid phosphatase: androgenic control of isoelectric focusing patterns.. Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire. 1983 July; 61. (7): 744-9  Published
Tenniswood MP, Abrahams PP, Bird CE, Clark AF. . Age-associated changes in acid phosphatase characteristics in rat ventral prostate and other organs.. Archives of andrology. 1982 December; 9. (4): 283-91  Published
Clark AF, Tandler B, Vignos PJ. . Glucocorticoid-induced alterations in the rabbit heart.. Laboratory investigation; a journal of technical methods and pathology. 1982 December; 47. (6): 603-10  Published
Bird CE, Masters V, Sterns EE, Clark AF. . Effects of aminoglutethimide on delta 5-androstenediol metabolism in postmenopausal women with breast cancer.. Cancer research. 1982 November; 42. (11): 4797-800  Published
Tenniswood M, Bird CE, Clark AF. . The role of androgen metabolism in the control of androgen action in the rat prostate.. Molecular and cellular endocrinology. 1982 June; 27. (1): 89-96  Published
Tenniswood M, Abrahams P, Winterton V, Bird CE, Clark AF. . Binding of testosterone, 5 alpha-dihydrotestosterone and 5 alpha-androstane (3 alpha- and 3 beta-), 17 beta-diols to serum proteins in the rat.. Journal of steroid biochemistry. 1982 May; 16. (5): 617-20  Published
Clark AF, Gerken TA, Hogg RW. . Proton nuclear magnetic resonance spectroscopy and ligand binding dynamics of the Escherichia coli L-arabinose binding protein.. Biochemistry. 1982 April 27; 21. (9): 2227-33  Published
Clark AF, Capra JD. . Ubiquitous nonimmunoglobulin p-azobenzenearsonate-binding molecules from lymphoid cells.. The Journal of experimental medicine. 1982 February 01; 155. (2): 611-6  Published
Bird CE, Tremblay J, Masters V, Clark AF. . Delta 5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal post-menopausal women.. Acta endocrinologica. 1982 February; 99. (2): 309-13  Published
Clark AF, Vignos PJ. . The role of proteases in experimental glucocorticoid myopathy.. Muscle & nerve. 1981 May - June; 4. (3): 219-22  Published
Clark AF, Roman IJ. . Mg2+ inhibition of Na2+-stimulated Ca2+ release from brain mitochondria.. The Journal of biological chemistry. 1980 July 25; 255. (14): 6556-8  Published
Clark AF, Vignos PJ. . Experimental corticosteroid myopathy: effect on myofibrillar ATPase activity and protein degradation.. Muscle & nerve. 1979 July - June; 2. (4): 265-73  Published
Farrell DF, MacMartin MP, Clark AF. . Multiple molecular forms of certain lysosomal enzymes separated by isoelectric focusing on cellulose acetate membranes.. Clinica chimica acta; international journal of clinical chemistry. 1978 October 02; 89. (1): 145-55  Published
Bird CE, Morrow L, Fukumoto Y, Marcellus S, Clark AF. . Delta5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal men and women.. The Journal of clinical endocrinology and metabolism. 1976 December; 43. (6): 1317-22  Published
Tenniswood M, Bird CE, Clark AF. . Acid phosphatases: androgen dependent markers of rat prostate.. Canadian journal of biochemistry. 1976 April; 54. (4): 350-7  Published
Clark AF, Swanson PD, Stahl WL. . Increase in dissociation rate constants of cardiotonic steroid-brain (Na+ + K+)-ATPase complexes by reduction of the unsaturated lactone.. The Journal of biological chemistry. 1975 December 25; 250. (24): 9355-9  Published
Van Doorn EJ, Burns B, Wood D, Bird CE, Clark AF. . In vivo metabolism of 3H-dihydrotestosterone and 3H-androstanediol in adult male rats.. Journal of steroid biochemistry. 1975 November - June; 6. (11-12): 1549-54  Published
Clark AF, Marcellus S, deLory B, Bird CE. . Plasma testosterone free index: a better indicator of plasma androgen activity?. Fertility and sterility. 1975 October; 26. (10): 1001-5  Published
Lee DK, Bird CE, Clark AF. . In vivo metabolism of 3H-testosterone in adult male rats: effects of estrogen administration.. Steroids. 1975 July; 26. (1): 137-47  Published
Farrell DF, Clark AF, Scott CR, Wennberg RP. . Absence of pyruvate decarboxylase activity in man: a cause of congenital lactic acidosis.. Science (New York, N.Y.). 1975 March 21; 187. (4181): 1082-4  Published
Patterson DC, Clark AF, Bird CE. . Testosterone delta 4-reductase activity in rat liver: hormonal control in vivo.. The Journal of endocrinology. 1974 October; 63. (1): 181-9  Published
Bruce AW, Sira SS, Clark AF, Awad SA. . The problem of catheter encrustation.. Canadian Medical Association journal. 1974 August 03; 111. (3): 238-9 passim  Published
Bird CE, Choong A, Knight L, Clark AF. . Kinetics of 5 alpha-androstane-3 alpha, 17 beta-diol metabolism in normal men and women.. The Journal of clinical endocrinology and metabolism. 1974 March; 38. (3): 372-5  Published
Lee DK, Janikowsky A, Bird CE, Clark AF. . Kinetics of (1,2-3H)-testosterone metabolism in normal adult male rats: effects of estrogen administration.. Journal of steroid biochemistry. 1974 February; 5. (1): 27-32  Published
Van Doorn EJ, Nduaguba JC, Clark AF. . Studies on partially purified pig liver steroid delta 4-5 beta-reductase activity.. Canadian journal of biochemistry. 1973 December; 51. (12): 1661-8  Published
Lee DK, Bird CE, Clark AF. . In vitro effects of estrogens on rat prostatic 5 alpha-reduction of testosterone.. Steroids. 1973 November; 22. (5): 677-85  Published
Clark AF, Carson GD, Delory B, Clemow ME, Bird CE. . Effects of oestrogen administration on testosterone metabolism in normal men.. Clinical endocrinology. 1973 October; 2. (4): 361-8  Published
Van Doorn EJ, Clark AF. . In vitro studies on the inhibition of pig liver steroid delta4-5beta-reductase activity by naturally occurring and synthetic estrogens.. Biochimica et biophysica acta. 1973 June 06; 309. (2): 254-62  Published
Lee DK, Young JC, Tamura Y, Patterson DC, Bird CE, Clark AF. . In vitro effects of estrogens on the 4 -reduction of testosterone by rat prostate and liver preparations.. Canadian journal of biochemistry. 1973 June; 51. (6): 735-40  Published
Clark AF, Villemez CL. . An artificial mannosyl acceptor for GDP-D-mannose: lipid phosphate transmannosylase from Phaseolus aureus.. FEBS letters. 1973 May 15; 32. (1): 84-6  Published
Clark AF, Bird CE. . Binding of 5 -androstane-3,17 -diol to human plasma proteins.. The Journal of endocrinology. 1973 May; 57. (2): 298  Published
Bird CE, Clark AF. . Metabolic clearance rates and metabolism of mestranol and ethynylestradiol in normal young women.. The Journal of clinical endocrinology and metabolism. 1973 February; 36. (2): 296-302  Published
Volp テゥ R, Killinger D, Bird C, Clark AF, Friesen H. . Idiopathic galactorrhea and mild hypogonadism in a young adult male.. The Journal of clinical endocrinology and metabolism. 1972 November; 35. (5): 684-92  Published
Clark AF, Villemez CL. . The Formation of beta, 1 --> 4 Glucan from UDP-alpha-d-Glucose Catalyzed by a Phaseolus aureus Enzyme.. Plant physiology. 1972 September; 50. (3): 371-374  Published
Clark AF, Calandra RS, Bird CE. . Kinetics of [3H]-testosterone metabolism in normal young men: effects of medroxyprogesterone acetate (provera) administration.. Journal of steroid biochemistry. 1972 September; 3. (5): 837-42  Published
Bird CE, Clark AF. . Kinetics of 3H-5 -dihydrotestosterone metabolism in normal men and women and men with prostatic carcinoma; effects of estrogen administration in men.. The Journal of clinical endocrinology and metabolism. 1972 March; 34. (3): 467-72  Published
Nduaguba JC, Clark AF. . Conversion of testosterone to androstenedione by the nuclear fraction of pig liver.. Endocrinology. 1971 July; 89. (1): 135-42  Published
Nduaguba JC, Clark AF. . Steroid delta 4-reductases of pig lver: partial purification of testosterone 5 beta-reductase.. Canadian journal of biochemistry. 1971 March; 49. (3): 385-92  Published
Bird CE, Clark AF. . A single method for determination of urine steroids. I. Levels of testosterone, epitestosterone and 17-ketosteroid fractions. II. Specific activities of testosterone, androsterone and etiocholanolone and production rate of testosterone following administration of labelled testosterone.. Clinical biochemistry. 1970 September; 3. (3): 231-44  Published
Villemez CL, Clark AF. . A particle bound intermediate in the biosynthesis of plant cell wall polysaccharides.. Biochemical and biophysical research communications. 1969 July 07; 36. (1): 57-63  Published
Bird CE, Green RN, Clark AF. . Effect of the administration of estrogen on the disappearance of 3H-testosterone in the plasma of human subjects.. The Journal of clinical endocrinology and metabolism. 1969 January; 29. (1): 123-6  Published
CLARK AF, RAESIDE JI, SOLOMON S. . STUDIES ON THE URINARY EXCRETION OF 17-KETOSTEROIDS BY THE DOMESTIC PIG.. Endocrinology. 1965 March; 76: 427-33  Published
CLARK AF, SOLOMON S. . Effect of dehydroisoandrosterone on the in vivo conversion of 17Alpha-hydroxypregnenolone to urinary 11-desoxy-17-ketosteroids.. The Journal of clinical endocrinology and metabolism. 1963 May; 23: 481-8  Published
MORSE WI, CLARK AF, MacLEOD SC, ERNST WA, GOSSE CL. . Urine estrogen responses to human chorionic gonadotropin in young, old and hypogonadal men.. The Journal of clinical endocrinology and metabolism. 1962 July; 22: 678-82  Published
Millar JC, Pang IH, Wang WH, Wang Y, Clark AF. . Effect of immunomodulation with anti-CD40L antibody on adenoviral-mediated transgene expression in mouse anterior segment.. Molecular vision; 14: 10-9  Published
Libby RT, Howell GR, Pang IH, Savinova OV, Mehalow AK, Barter JW, Smith RS, Clark AF, John SW. . Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.. BMC neuroscience; 8: 108  Published
Yuan C, Zins EJ, Clark AF, Huang AJ. . Suppression of keratoepithelin and myocilin by small interfering RNAs (siRNA) in vitro.. Molecular vision; 13: 2083-95  Published
Agarwal N, Agarwal R, Kumar DM, Ondricek A, Clark AF, Wordinger RJ, Pang IH. . Comparison of expression profile of neurotrophins and their receptors in primary and transformed rat retinal ganglion cells.. Molecular vision; 13: 1311-8  Published
Liu X, Clark AF, Wordinger RJ. . Expression of ciliary neurotrophic factor (CNTF) and its tripartite receptor complex by cells of the human optic nerve head.. Molecular vision; 13: 758-63  Published
Pang IH, Zeng H, Fleenor DL, Clark AF. . Pigment epithelium-derived factor protects retinal ganglion cells.. BMC neuroscience; 8: 11  Published
Kim CY, Kuehn MH, Clark AF, Kwon YH. . Gene expression profile of the adult human retinal ganglion cell layer.. Molecular vision; 12: 1640-8  Published
Steely HT, Dillow GW, Bian L, Grundstad J, Braun TA, Casavant TL, McCartney MD, Clark AF. . Protein expression in a transformed trabecular meshwork cell line: proteome analysis.. Molecular vision; 12: 372-83  Published
Kirwan RP, Fenerty CH, Crean J, Wordinger RJ, Clark AF, O'Brien CJ. . Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro.. Molecular vision; 11: 798-810  Published
Terry DE, Clark AF. . Glycosaminoglycans in the three lobes of the rat prostate following castration and testosterone treatment.. Biochemistry and cell biology = Biochimie et biologie cellulaire; 74. (5): 653-8  Published
Terry DE, Clark AF. . Influence of testosterone on chondroitin sulphate proteoglycan in the rat prostate.. Biochemistry and cell biology = Biochimie et biologie cellulaire; 74. (5): 645-51  Published
Montpetit M, Abrahams P, Clark AF, Tenniswood M. . Androgen-independent epithelial cells of the rat ventral prostate.. The Prostate; 12. (1): 13-28  Published
Orlowski J, Clark AF. . Effect of a 4-methyl-4-aza steroid on androgen metabolism by rat ventral prostate epithelial and stromal cell cultures: selective inhibition of 5 alpha-reductase activity.. The Prostate; 13. (4): 289-97  Published
McDonald G, Clark AF, Flynn TG. . Quantitation by radioimmunoassay of aldose reductase (ALR2) in normal and diabetic rats.. Progress in clinical and biological research; 232: 367-75  Published
Bird CE, Masters V, Sterns EE, Clark AF. . Effects of tamoxifen on testosterone metabolism in postmenopausal women with breast cancer.. Clinical and investigative medicine. Mテゥdecine clinique et experimentale; 8. (2): 97-102  Published
Bird CE, Masters V, Clark AF. . Dehydroepiandrosterone sulfate: kinetics of metabolism in normal young men and women.. Clinical and investigative medicine. Mテゥdecine clinique et experimentale; 7. (2): 119-22  Published
McElnea EM, Quill B, Docherty N, Irnaten M, Siah WF, CLARK AF, O達rien CJ, Wallace DM. Oxidant-induced calcium overload in human lamina cribrosa cells from glaucoma donors. Molecular Vision; 17: 1182-1191
Tenniswood MP, Abrahams PP, Bird CE, Clark AF. . Small doses of 5 alpha-dihydrotestosterone mimic the effects of 5 alpha-androstane-3 beta, 17 beta-diol on acid phosphatase activity in the adult rat prostate gland.. Molecular and cellular endocrinology; 22. (2): 223-9  Published
Millar JC, Pang I-H, CLARK AF.. Aqueous humor dynamics in the mouse by constant flow infusion. 2008 ARVO Annual Meeting: Abstract 354  Published
Tenniswood M, Bird CE, Clark AF. . Kinetics of in vivo 5 alpha-androstane-3 beta, 17 beta-diol metabolism in adult normal and castrated male rats.. Journal of steroid biochemistry; 14. (2): 199-203  Published
Rapport RL, Harris AB, Lockard JS, Clark AF. . Na+ + K+-ATPase in serially excised segments of epileptic monkey cortex.. Epilepsia; 22. (1): 123-7  Published
Bird CE, Cook S, Owen S, Sterns EE, Clark AF. . Plasma concentrations of C-19 steroids, estrogens, FSH, LH and prolactin in post-menopausal women with an without breast cancer.. Oncology; 38. (6): 365-8  Published
Jacobs FA, Flynn TG, Clark AF. . Characterization of separated prostatic and phosphatase forms in normal and castrated rats.. Molecular and cellular endocrinology; 18. (3): 177-87  Published
Bird CE, Cook SJ, Dressel DE, Clark AF. . Plasma C19-delta 5-steroid levels during normal human pregnancy.. Clinical biochemistry; 13. (3): 126-8  Published
Bruce AW, Mahan DE, Morales A, Clark AF, Belville WE. . An objective look at acid phosphatase determinations: a comparison of biochemical and immunological methods.. British journal of urology; 51. (3): 213-7  Published
Farrell DF, MacMartin MP, Clark AF. . Multiple molecular forms of arylsulfatase A in different forms of metachromatic leukodystrophy (MLD).. Neurology; 29. (1): 16-20  Published
Van Doorn EJ, Bird CE, Clark AF. . Nuclear 3alpha-hydroxysteroid dehydrogenase (3alphaOHD) activity for 5alpha-dihydrotestosterone in the rat prostate.. Endocrine research communications; 2. (8): 471-87  Published
Bird CE, Green RN, Calandra RS, Connolly JG, Clark AF. . Kinetics of 3 H-testosterone metabolism in patients with carcinoma of the prostate: effects of oestrogen administration.. Acta endocrinologica; 67. (4): 733-9  Published
Pang I-H, Wang W-H, Millar JC, CLARK AF. Intraocular pressure measurement in rodents. Zhonghua Yan Ke Za Zhi; 2008: 465-468  Published
Quill B, Docherty N, CLARK AF, O達rien CJ. The effect of graded cyclic stretch on ECM remodeling gene expression profiles in cultured primary human lamina cribrosa cells. Invest Ophthalmol Vis Sci; 52: 1908-1915  Published
O坦eilly S, Pollock N, Currie L, Paraoan L, AF CLARK, Grierson I. Inducers of cross-linked actin networks (CLANs) in trabecular meshwork cells  Submitted
Kirwan RP, CLARK AF, O達rien CJ, Leonard MO. Hypoxia regulated transcription of genes mediating apoptosis, neurogenesis, and extracellular matrix remodeling in optic nerve lamina cribrosa cells  Submitted
Zode GS, Keuhn MH, Nishimura DY, Searby CC, Mohan K, Grozdanic SD, Bugge K, Anderson MG, CLARK AF, Stone EM, Sheffield VC. A chemical chaperone rescues glaucoma by reducing ER stress in a murine model of primary open angle glaucoma. J. Clin. Invest.  Accepted/In-press
Zode GS, Sethi A, Brun-Zinkernagel A-M, Chang I-F, CLARK AF, Wordinger RJ. Transforming growth factor-イ2 increases extracellular matrix proteins in the optic nerve head cells via activation of Smad signaling pathway. Molecular Vision; 17: 1745-1758  Published
Zode GS, Sethi A, Brun-Zinkernagel AM, Chang IF, Clark AF, Wordinger RJ. Transforming growth factor-ホイ2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway.. Molecular vision; 17: 1745-58  Published
McDowell C, Luan T, Zhang Z, Putliwala T, Millar JC, John SWM, Pang I-H, CLARK AF. Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice  Submitted
Mao W, Tovar-Vidales T, Yorio T, Wordinger RJ, CLARK AF. Perfusion cultured bovine anterior segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension and glaucoma  Submitted
Bollinger KE, Crabb JS, Yuan X, Putliwala T, CLARK AF, Crabb JW. TGFb2-induced proteomic changes in trabecular meshwork cells: new mechanistic insights into primary open angle glaucoma  Submitted
Howell GR, Sota I, Nair S, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, Harmon K, Barbay JM, Porciatti V, Anderson MG, Smith RS, CLARK AF, Libby RT, John SWM. Irradiation of an eye modifies transendothelial migration of monocytes and prevents glaucoma in mice  Submitted
Bollinger KE, Crabb JS, Yuan X, Putliwala T, CLARK AF, Crabb JW. Dexamethasone-induced proteomic changes in trabecular meshwork cells: insights into the molecular basis of steroid-induced glaucoma  Submitted
Taylor AF, CLARK AF, Wordinger RJ. Characterization of follistatin and associated molecules in human trabecular meshwork cells and tissues. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 4643  Published
 
Books   More...    Close... 
Wax M, CLARK A, Civan MM. Chapter 10.3 Mechanisms of glaucoma. Yanoff & Ducker. Ophthalmology, 4th Edition. 2014 January: 1012-1018  Published
CLARK AF. Future glaucoma medical therapies: what痴 in the pipeline?. glaucoma medical therapies: what痴 in the pipeline?. The Glaucoma Book: A Practical, Evidence-Based Approach to Patient Care. 2010 - ; Springer. (Chapter 88): 981-985  Published
Pang I-H and CLARK. Animal Models for Retinal Diseases. Pang I-H and CLARK AF. Non-primate models of glaucoma retinopathy and optic neuropathy. 2010  Published
. Animal Models for Retinal Diseases. Pang I-H and CLARK AF (editors). 2010  Published
CLARK AF. Encyclopedia of the Eye. Steroid-induced ocular hypertension and effects of glucocorticoids on the trabecular meshwork. 2010  Published
CLARK AF. The Glaucoma Book: A Practical Evidence-Based Approach to Patient Care. John Samples & Paul Schacknow. Future glaucoma medical therapies: what's in the pipeline?. 2010: 981-985  Published
Civan M, Clark AF, Wax M. Mechanisms of Glaucoma. Yanoff, Ducker.. Ophthalmology, 3rd Edition. 2009: 1108-1116  Published
CLARK AF, Zhang X, Yorio. Ocular Diseases: Mechanisms and Management. Levin & Alperts. Steroid-induced glaucoma. 2009: 166-175  Published
Steely HT, CLARK AF. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd.. Eye Proteomics. 2009: 1-11  Published
. Ocular Theraeputics: Eye on New Discoveries. Yorio T, CLARK AF, Wax M. Academic Press/Elsevier, New York. 2008  Published
Yorio T, CLARK AF, Wax M. The eye as a drug target. Yorio T, CLARK AF, Wax M. Ocular Therapeutics:Eye on New Discoveries. 2008: 3-6  Published
Pang I-H, CLARK AF. IOP as a target inflow and outflow pathways. Thomas Yorio, Abbot F. Clark, Martin Wax. Ocular Therapeutics: Eye on New Discoveries. 2008: 45-67  Published
Pang IH, Clark AF. The Eye's Aqueous Humor. Civan M. Outflow signaling mechanisms and new therapeutic strategies for the control of intraocular pressure. 2008: 428-469  Published
Robertson SM, Davis AA, Dahlin DC, CLARK AF. Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics. Tombran-Tink J, Barnstable CJ. Anecortave acetate: a novel ocular angiostatic agent. 2006: 341-354  Published
Steely HT, CLARK AF. Nature Encyclopedia of the Human Genome, Volume 2. Cooper DN. Eye: Proteomics. 2003: 434-439  Published
CLARK AF, Morrison JC. Glaucoma: Science and Practice. Morrison JC, Pollack IP. Corticosteroid glaucoma. 2002: 197-206  Published
DeFaller JM, CLARK AF. Pterygium. HR Taylor. A new pharmacological treatment for angiogenesis. 2000: 159-181  Published
CLARK AF, Browder S, Steely HT, Wilson K, Cantu-Crouch D, McCartney MD. Optic Nerve in Glaucoma. Drance SM. Cell biology of the human lamina cribrosa. 1995: 79-105  Published
 
Abstracts and Others   More...    Close... 
Liu B, Kilpatrick JI, Lukasz B, Wallace DM, CLARK AF, O達rien CJ, Jarvis SP.. Influence of substrate stiffness on the proliferation and mechanical properties of normal and glaucoma trabecular meshwork (NTM and GTM) cells.. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #60  Published
McDowell CM, Luan T, Pang I-H, Wordinger RJ, CLARK AF.. Effect of transforming growth factor beta-2 signaling and gremlin induction on fibronectin, ocular hypertension, and optic nerve damage in mice.. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #376  Published
Silverman S, McDowell CM, Kim B-J, Wordinger RJ, CLARK AF. Complement and glial activitiy in the retinocollicular pathway of mice in a novel model of glaucoma. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #421  Published
Liu Y, Zhang Z, Wordinger RJ, Libby RT, Pang I-H, CLARK AF. Differential activation of p38 and c-jun N-terminal kinase in the visual pathway following optic nerve crush. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #422  Published
Putliwala T, Liu Y, Wordinger RJ, CLARK AF. Role of neuritin 1 in response to optic nerve crush. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #431  Published
Wallace DM, CLARK AF, Oliver N, Crean JK, O達rien CJ. Connective tissue growth factor induction of lysyl oxidase (LOX) enzymes expression in human trabecular meshwork cells is reduced by FG-3019. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #763  Published
Hughes EL, Docherty NG, Crean JK, CLARK AF, Wallace DM, O達rien CJ. The retinal pigment epithelial cell and peripapillary atrophy: potential mediators of glaucomatous optic disc cupping?. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #764  Published
CLARK AF. Trabecular meshwork extracellular matrix changes in glaucoma. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #1231  Published
Dibas A, CLARK AF, Yorio T. Requirement for the proteasome, ATP, and exportin-1 in the nuclear export of glucocorticoid alpha (GRア) receptor following DEX-treatment in human trabecular meshwork cell-line (NTM5). 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #1972  Published
Kim BJ, Liu Y, Silverman S, Wordinger RJ, Libby RT, Pang I-H, CLARK AF. Protective effects of JNK inhibition in retinal ganglion cells and in retinal ischemia/reperfusion injury. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #2624  Published
Braun TA, Wagner AH, DeLuca AP, Casavant T, Sheetz TE, CLARK AF, Mullins RF, Stone EM. The ocular tissue database. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #3383  Published
Mao W, Liu Y, Wordinger RJ, CLARK AF. A magnetic bead-based method for mouse trabecular meshwork cell isolation. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #3527  Published
Tovar-Vidales T, Fitzgerald AM, CLARK AF, Wordinger RJ. Transforming growth factor-b2 (TGF-b2) induces expression of biologically active bone morphogenetic protein-1 (BMP-1) in human trabecular meshwork cells. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #3531  Published
Medina-Ortiz WE, Wordinger RJ, CLARK AF. Effect of cellular and plasma fibronectin isoforms on normal human trabecular meshwork cells. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #3541  Published
Mody AA, Wordinger RJ, CLARK AF. Bone morphogenetic protein 4 induces ID1 and ID3 transcription factors in trabecular meshwork cells. 2013 Annual Meeting of Association for Research in Vision and Ophthalmology. 2013 May: Abstract #4990  Published
Sethi A, Wordinger RJ, CLARK AF. Gremlin alters the trabecular meshwork extracellular matrix via TGFb/Smad signaling. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 5836. 2010  Published
Tovar-Vidales T, CLARK AF, Wordinger RJ. Effects of TGFb2, BMPs 2/5/7, and gremlin on fibronectin in human trabecular meshwork cells. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 3209. 2010  Published
Jain A, Wordinger RJ, Yorio T, CLARK AF. SR splicing proteins: key players regulating GRa/GRb ratio and glucocorticoid response in trabecular meshwork cells. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 3216. 2010  Published
Fitzgerald A, Benz C, Wordinger RJ, CLARK AF. Follistatin and activin expression in human trabecular meshwork cells. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 3212. 2010  Published
Crabb JS, Bollinger KE, Yuan X, Yue X, CLARK AF, Crabb JW. Quantitative proteomic analysis of dexamethasone-treated human trabecular meshwork cells.. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 3206. 2010  Published
Siah WF, Wallace DM, CLARK AF, Flanagan JG, O達rien CJ. The relationship between oxidative stress, calcium homeostasis and extracellular matrix remodeling in human lamina cribrosa cells. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 2705. 2010  Published
Quill BD, Docherty NG, Wallace DM, O達rien CJ, CLARK AF. Verapamil blocks mechanical strain induced upregulation of TGF-b1 mRNA in lamina cribrosa cells. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 3168. 2010  Published
Wallace D, Irnaten M, Barry R, Duff A, Docherty N, Quill B, CLARK A, O達rien C. Abnormal calcium homeostasis in glaucomatous lamina cribrosa cells. 2010 Annual Meeting Association for Research in Vision and Ophthalmology, Abstract 6104. 2010  Published
Putliwala T, Bollinger KE, Yuan X, Yue X, Wordinger RJ, Crabb JW, CLARK AF. Pathogenicity of glaucoma assessed through shotgun proteomic analysis of TGF-b2 treated human trabecular meshwork cells. 2010 International Conference on Bioinformatics and Computational Biology. 2010  Accepted/In-press
Mao W, Wordinger RJ, CLARK AF. Role of the canonical Wnt signaling pathway in glaucoma. 2010 ICER Meeting. 2010  Published
Quill BD, McElnea EM, Docherty NG, Irnaten M, Barry RC, CLARK AF, O達rien CJ. Elevated intracellular free calcium in glaucoma derived lamina cribrosa cells. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 2790  Published
CLARK AF, Zode GS, Sethi A, Wordinger RJ. TGFb2 increases extracellular matrix proteins in human optic nerve head cells via activation of the Smad signaling pathway. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4318  Published
Hoare M-J, Job R, Wade NC, Brotchie D, Grierson I, CLARK AF. Effects of bovine aqueous humor (BAH) on cross linked actin networks (CLANs) in cultured bovine trabecular meshwork (BTM) cells. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4876  Published
Hoare M-J, Job R, Wade NC, Brotchie D, Grierson I, CLARK AF. Effects of bovine aqueous humor (BAH) on cross linked actin networks (CLANs) in cultured bovine trabecular meshwork (BTM) cells. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4876  Published
Cracknell KP, Zheng Y, Hoare M-J, Grierson I, CLARK AF. Cross-linked actin networks (CLANs) affect rigidity of the meshwork cell. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4877  Published
O坦eilly S, Brotchie D, Williams R, Grierson I, CLARK AF. Modulation of contraction of bovine trabecular meshwork cells by cross-linked actin networks (CLANs). 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4878  Published
Mao W, Wordinger RJ, CLARK AF. The existence of a canonical Wnt signaling pathway in GTM-3 cells. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4884  Published
Wordinger RJ, Tovar-Vidales T, CLARK AF. TGF-beta2 regulation of tissue transglutaminase (TGM2) expression in human trabecular meshwork cells. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 4886  Published
Sethi A, Mao, W, Krishnamoorthy R, Wordinger RJ, CLARK AF. Transforming growth factor b induces extracellular matrix protein cross-linking enzyme lysyl oxidase and other LOX family proteins: implications for glaucoma. 2009 Annual Meeting Association for Research in Vision and Ophthalmology. 2009: Abstract 5720  Published
Sethi A, Waggoner M, Taylor A, Wordinger RJ, CLARK AF. Transforming growth factor b induces extracellular matrix protein crosslinking enzyme lysyl oxidase and other LOX family proteins. Annual Meeting of the American Society for Cell Biology. 2008: Abstract 864  Published
Wax, MB, CLARK AF.. A novel technique for assessing new druggable targets in glaucoma.. American Glaucoma Society Meeting. 1981 May - June  Published
Wang W-H, McNatt LG, CLARK AF. Effect of serum amyloid A on genome-wide gene expression in human TM cells. 2008 ARVO Annual Meeting. 1980 July 25: Abstract 1630  Published
Shepard AR, Nolan MJ, Millar JC, Pang I-H, Luan T, Jacobson N, Wax MB, CLARK AF, Knepper PA. CD44 overexpression causes ocular hypertension in the mouse. 2008 ARVO Annual Meeting. 1979 July - June: Abstract 2880  Published
Millar JC, Pang I-H, Wang W-H, Shepard AR, Wax MB, CLARK AF. Non-invasive measurement of intraocular pressure in the rat and mouse with the Tonolab rebound tonometer. 2008 ISOT Meeting. 1978 October 02  Submitted
Giovingo MC, Nolan MJ, Koga T, Yue BYJT, Wertz RD, Ritch R, Shepard A, CLARK AF, Wax MB, Knepper PA.. Aqueous humor sCD44 concentration in diabetes and primary opoen-angle glaucoma.. 2008 ARVO Annual Meeting: Abstract 1574  Published
Nolan MJ, Koga T, Yue BYJT, Giovingo MC, Shepard A, CLARK AF, Wax MB, Samples JR, Knepper PA. Caveolin-1 expression in trabecular meshwork cells.. 2008 ARVO Annual Meeting: Abstract 1627  Published
Zode G, CLARK AF, Wordinger RJ.. Gemlin increases extracellular matrix components via the TGF-b2 signaling pathway.. Experimental Biology Annual Meeting  Published
Millar JC, Pang I-H, CLARK AF.. Aqueous humor dynamics in the mouse by constant flow infusion. 2008 ARVO Annual Meeting: Abstract 354  Published
Craven ER, Robin AL. Feldman RM, Scheib SA, Dickerson JE, Landry TA, Wells DT, CLARK AF, Bergamini MVW. Control of IOP in open-angle glaucoma by anecortave acetate: a comparison of three doses and vehicle.. 2008 ARVO Annual Meeting: Abstract 1207  Published
Fleenor DL, Pang I-H, CLARK AF. Regulation of PAI-1 protein in human trabecular meshwork cells. 2008 ARVO Annual Meeting: Abstract 1631  Published
Do CW, Wang Z, Valiunas V, CLARK AF, Wax MB, Chatterton JE, Civan MM.. Regulation of gap junction coupling in bovine ciliary epithelium. 2008 ARVO Annual Meeting: Abstract 2103  Published
Chatterton JE, Sun D, Donohue DD, Fleenor DL, Pang I-H, Wax, MB, CLARK AF. Effect of siRNA-mediated ROCK inhibition on TGFb2-induced PAI-1 secretion. 2008 ARVO Annual Meeting: Abstract 3818  Published
Pang I-H, Fleenor DL, Hellberg PE, Zeng H, Johnson EC, Morrison JC, CLARK AF. The ocular hypotensive and neuroprotective effects of propentofylline.. 2008 ARVO Annual Meeting: Abstract 5509  Published
Dibas A, Jiang M, CLARK AF, Yorio T. Generation of human trabecular meshwork cell lines with fluorescently labeled glucocorticoid alpha and beta receptors. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 1506  Published
McDowell CM, Luan T, Millar C, Pang I-H, Wordinger RJ, CLARK AF. A new mouse model of human primary open-angle glaucoma. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 2440  Published
Wallace DM, McElnea EM, Quill BD, Irnaten M, CLARK AF, O達rien CJ. Reduced anti-oxidant potential in human lamina cribrosa cells from glaucoma donors. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 4591  Published
Pollock NM, O坦eilly S, Paraoan L, CLARK A, Grierson I. Is TGF-b2 the component in aqueous humor responsible for induction of cross-linked actin networks (CLANs) in trabecular meshwork cells?. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 4660  Published
Quill B, Docherty N, McElnea EM, Wallace D, CLARK AF, O達rien CJ. Calcium regulation of strain induced extracellular matrix genes in lamina cribrosa cells. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 5325  Published
Mao W, Tovar-Vidales T, Wordinger RJ, CLARK AF. Perfusion cultured bovine anterior eye segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension (OHT) and glaucoma. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 5922  Published
Crabb JW, Yuan X, Crabb JS, Putliwala TM, CLARK AF, Bollinger KE. Quantitative proteomic studies implicate mitochondrial dysfunction in the trabecular meshwork in glaucoma pathology. 2011 Annual Meeting of Association for Research in Vision and Ophthalmology: Abstract 6611  Published
Wallace D, McElnea E, Quill B, Docherty N, Irnaten M, Siah W, CLARK AF, O達rien C. Oxidative stress and calcium overload in human lamina cribrosa cells from glaucoma donors. 2011 World Glaucoma Congress: 102  Published
McElnea E, Quill B, Docherty N, Wallace D, Farrell, CLARK AF, O達rien C. Lipofuscin accumulation in glaucomatous human lamina cribrosa cells. 2011 World Glaucoma Congress: 103  Published
 
Faculty Development / Professional Meetings   More...    Close... 
August 8 2015Trabecular meshwork and aqueous humor dynamics meeting
  Role: Invited Speaker Scope: International 
August 7 2015Trabecular Meshwork & Aqueous Humor Dynamics Study Group
  Role: Chair/Organizer Scope: International 
April 11 2015Discovery of new pathogenic pathways in glaucoma
  Role: Invited Speaker Scope: Local 
January 7 2015Understanding myocilin glaucoma
  Role: Invited Speaker Scope: National 
December 4 2014Meshwork Society Meeting
  Role: Chair/Organizer Scope: International 
October 29 2014Dean's Convocation: Annibel Musick Garner Lecture
  Role: Invited Speaker Scope: State/Regional 
October 28 2014Molecular pathogenesis of glaucoma - Ophthalmology Research
  Role: Invited Speaker Scope: State/Regional 
October 21 2014Glaucoma gene therapy approaches
  Role: Invited Speaker Scope: National 
August 28 2014Glaucoma Reseasrch Society
  Role: Invited Speaker Scope: International 
August 28 2014Glaucoma Research Society
  Role: Chair/Organizer Scope: International 
July 20 2014International Society for Eye Research XXI Biennial Meeting
  Role: Chair/Organizer Scope: International 
July 20 2014International Society for Eye Research XXI Biennial Meeting
  Role: Invited Speaker Scope: International 
July 17 2014Dept. Ophthalmology Lecture Series
  Role: Invited Speaker Scope: Local 
April 26 2014University of Iowa Grand Rounds
  Role: Invited Speaker Scope: State/Regional 
February 12 2014Loris and David Rich Research to Prevent Blindness Lecture
  Role: Invited Speaker Scope: State/Regional 
December 14 2013Meshwork Society Meeting
  Role: Invited Speaker Scope: International 
September 29 2013ISER Sarasota Symposium on Molecular Mechanisms of Glaucoma
  Role: Invited Speaker Scope: International 
June 18 2013Institut de la Vision
  Role: Invited Speaker Scope: International 
May 5 20132013 ARVO Annual Meeting
  Role: Invited Speaker Scope: International 
May 5 20132013 ARVO Annual Meeting
  Role: Chair/Organizer Scope: International 
April 15 20133rd International Conference on Clinical and Experimental Ophthalmology
  Role: Chair/Organizer Scope: International 
April 15 20133rd International Conference on Clinical and Experimental Ophthalmology
  Role: Invited Speaker Scope: International 
January 17 2013Cole Eye Institute/Cleveland Clinic
  Role: Invited Speaker Scope: National 
October 19 20128th International Symposium on Uveitis
  Role: Invited Speaker Scope: International 
July 21 2012International Society for Eye Resdearch
  Role: Invited Speaker Scope: International 
July 21 2012International Society for Eye Resdearch
  Role: Chair/Organizer Scope: International 
May 5 2012ARVO
  Role: Chair/Organizer Scope: International 
May 5 2012ARVO
  Role: Invited Speaker Scope: International 
May 4 2012ARVO/Pfize Institute
  Role: Invited Speaker Scope: International 
October 22 2011American Academy of Ophthalmology
  Role: Invited Speaker Scope: International 
June 29 2011World Glaucoma Congress
  Role: Invited Speaker Scope: International 
June 16 20116th Annual Texas Conference on Health Disparities: An Eye Towards the Future
  Role: Chair/Organizer Scope: National 
June 16 20116th Annual Texas Conference on Health Disparities; An Eye Towards the Future
  Role: Invited Speaker Scope: National 
June 12 20117th Drabkin Eye Disease Symposium
  Role: Invited Speaker Scope: National 
March 3 2011American Glaucoma Society
  Role: Invited Speaker Scope: National 
February 16 2011Association for Ocular Pharmaology & Therapeutics Meeting
  Role: Chair/Organizer Scope: International 
January 7 2011University of Alberta
  Role: Invited Speaker Scope: International 
December 11 2010Meshwork Society Meeting
  Role: Invited Speaker Scope: National 
September 10 2010Glaucoma Research Foundation Catalyst Meeting
  Role: Invited Speaker Scope: International 
July 20 2010Discovery of new glaucoma therapeutic targets
  Role: Invited Speaker Scope: International 
July 18 2010Intl Society for Eye Resarch (Organizer, Physiology & Pharmacology Section)
  Role: Chair/Organizer Scope: International 
May 4 2010Discovery of new pathogenic pathways in the glaucomatous trabecular meshwork
  Role: Invited Speaker Scope: International 
May 4 2010ARVO Special Interest Group (SIG)
  Role: Chair/Organizer Scope: International 
May 3 2010The role of Wnt signaling in glaucomatous ocular hypertension
  Role: Invited Speaker Scope: International 
April 16 2010Discovery of new glaucoma pathogenic pathways
  Role: Invited Speaker Scope: State/Regional 
December 5 2009BMP antagonist gremlin alters TM ECM via activation of Smad signaling
  Role: Invited Speaker Scope: International 
October 5 2009Discovery of new glaucoma pathogenic mechanisms
  Role: Invited Speaker Scope: State/Regional 
July 10 2009New insights into glaucoma pathogenesis
  Role: Invited Speaker Scope: State/Regional 
July 10 2009New pathogenic pathways for glaucoma
  Role: Invited Speaker Scope: State/Regional 
May 6 2009Effects of dexamethasone and TGFb on TM cytoskeleton and aqueous outflow resistance
  Role: Invited Speaker Scope: National 
May 4 2009Optic nerve head glial activation: good or bad?
  Role: Invited Speaker Scope: National 
May 4 2009ARVO Glaucoma Minisymposium
  Role: Chair/Organizer Scope: National 
February 5 2009Pathogenic roles for TGFb2 in glaucoma
  Role: Invited Speaker Scope: Local 
November 20 2008Discovery of new glaucoma pathogenic pathways
  Role: Invited Speaker Scope: National 
November 11 2008A new paradigm for glaucoma drug discovery
  Role: Invited Speaker Scope: Local 
September 27 2008Steroids and the Eye session
  Role: Chair/Organizer Scope: International 
September 27 2008Role of glucocorticoid receptor-beta (GRb) in steroid responsiveness and glaucoma
  Role: Invited Speaker Scope: International 
April 30 2008Perfusion organ culture of anterior segments: a twenty-year odyssey of practice and pitfalls.
  Role:  Scope: National/International 
April 24 2008Targeting glia for neuroprotection in glaucoma.
  Role:  Scope: National/International 
March 13 2008Discovery of new glaucoma pathogenic pathways.
  Role:  Scope: Local 
December 1 2007An alternatively spliced variant of the glucocorticoid receptor, GRb, in human trabecular meshwork cells.
  Role:  Scope: International 
January 5 2007Tissue transglutaminase expression and activity in normal and glaucomatous trabecular meshwork cells
 Association for Research in Vision and Ophthalmology, Abstract 2059 Role:  Scope: National/International 
January 5 2007Bone morphogenic protein 4 inhibits TGF-b2 signaling in optic nerve head astrocytes and lamina cribrosa cells: extracellular matrix modulation by gremlin in glaucoma
 Association for Research in Vision and Ophthalmology, Abstract 3268 Role:  Scope: National/International 
January 1 2007A functional WNT signaling pathway in the trabecular meshwork that regulates intraocular pressure
 Association for Research in Vision and Ophthalmology, Abstract 1142 Role:  Scope: National/International 
January 1 2007Profiling gene expression of human ocular tissues
 Association for Research in Vision and Ophthalmology, Abstract 3797 Role:  Scope: National/International 
January 1 2007Glaucoma-causing myocilin mutants require the peroxisomal targeting signal-1 receptor (PTS1R) to elevated intraocular pressure
 Association for Research in Vision and Ophthalmology, Abstract 4806 Role:  Scope: National/International 
January 1 2007Toxicity of capsaicin receptor TRPV1 agonists on cultured adult rat retinal ganglion cells
 Association for Research in Vision and Ophthalmology, Abstract 4943 Role:  Scope: National/International 
January 1 2007An extensive microarray study of DBA/2J: a resource for molecular characterization of glaucoma
 Association for Research in Vision and Ophthalmology, Abstract 1554 Role:  Scope: National/International 
January 1 2007Comparison of gene expression in cultured human optic nerve head astrocytes and lamina cribrosa cells
 Association for Research in Vision and Ophthalmology, Abstract 5913 Role:  Scope: National/International 
January 1 2007Multidrug resistance proteins and the human trabecular meshwork
 Association for Research in Vision and Ophthalmology, Astract 2056 Role:  Scope: National/International 
January 1 2007Immunophilins-FK506 binding proteins 51 and 52: Role in nuclear transport of the glucocorticoid receptor and glucocorticoid responsiveness
 Association for Research in Vision and Ophthalmology, Abstract 1552 Role:  Scope: National/International 
January 1 2007Cross-linked actin networks (CLANs) are identified in cells from normal and glaucomatous trabecular meshwork in situ
 Association for Research in Vision and Ophthalmology, Abstract 2076 Role:  Scope: National/International 
January 1 2007Cross-linked actin networks (CLANs) in the cells of the bovine optic nerve head
 Association for Research in Vision and Ophthalmology, Abstract 3270 Role:  Scope: National/International 
January 1 2006Glaucoma-causing myocilin mutations require association with peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure
 American Society of Human Genetics Role:  Scope: National/International 
January 1 2006PAI-1 modulation of trabecular meshwork cellularity
 American Society of Matrix Biology Role:  Scope: National/International 
January 1 2006Effect of vanilloid receptor-1 agonists on the survival of cultured adult rat retinal ganglion cells
 Society for Neuroscience Role:  Scope: National/International 
January 1 2006Glaucoma-causing mutations in myocilin lead to abnormal association with peroxisomal targetiing signal type 1 receptor (PTS1R) and elevated IOP
 American Society for Cell Biology Role:  Scope: National/International 
January 1 2006The effects of glaucomatous insults to optic nerve head cells
 NA Role:  Scope: Local 
November 11 2005Glaucoma genomics
 Columbia University, New York, NY Role:  Scope: State/Regional 
October 12 2005Gremlin, BMP, and TGFbeta in glaucoma
 San Francisco, CA Role:  Scope: State/Regional 
September 25 2005Cytokines in glaucoma: the good and the bad.
 Laguna Beach, CA Role:  Scope: State/Regional 
September 20 2005Preclinical models of retinal and choroidal neovascularization
 San Diego, CA Role:  Scope: State/Regional 
July 12 2005GRbeta in glaucoma.
 University of Iowa Role:  Scope: State/Regional 
June 15 2005Glaucoma pathogenesis: insights from genomics.
 Tel Aviv, Israel Role:  Scope: National/International 
April 21 2005Glaucoma discovery research
 Philadelphia, PA  Role:  Scope: National/International 
February 5 2005Cultured adult rat RGCs as a model for neuroprotection.
 Ft. Lauderdale, Florida Role:  Scope: State/Regional 
January 5 2005Glaucoma-caussing myocilin mutants associate with the peroxisomal targeting signal-1 receptor (PTSIR)
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Immunosuppression prolongs expression of adenoviral vector in mouse anteior segment
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Expression of p75NTR and nerve growth factor in human optic nerve head and retina
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Expression of BMP-related Smad signaling proteins in cells isolated from the human optic nerve head
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Effect of exogenous nerve growth factor (NGF) on the expression of MMPs and TIMPs by cells isolated from the human optic nerve head
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Protective effects of pigment epithelium-derived factor on cultured adult rat retinal ganglion cells
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Expression of neurotrophins and their receptors in primary and transformed rat retinal ganglion cells (RGC-5) and adult rat retina: a double immunofluorescent confocal study
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Effect of hypoxia on extra-cellular matrix gene expression in lamina cribrosa cells from the human optic nerve head
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Evidence that immunophilin and microtubules are involved in nuclear transport of glucocorticoid receptor beta
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005TGFb2-induced changes in trabecular meshwork matrix component expression: implications for intraocular pressure
 Fort Lauderdale, Florida Role:  Scope: National/International 
January 5 2005Suppression of myocilin expression by small interfering RNAs
 Fort Lauderdale, Florida Role:  Scope: National/International 
 
Administration
Director, North Texas Eye Research Institute
Director, Office of Postdoctoral Education
 
Community Engagement
Institutional Service   More...    Close... 
2010 - CurrentCBAN Promomotion and Tenure Committee
LocalSchool/Insitutional CommitteesCommittee Member
2010 - CurrentUNTHSC GSBS Promotion and Tenure Committee
LocalSchool/Insitutional CommitteesCommittee Member
2010 - CurrentPostdoctoral Education Office
LocalSchool/Insitutional CommitteesDirector
2008 - CurrentUNTHSC GSBS Graduate Council
LocalSchool/Insitutional CommitteesCommittee Member
2008 - CurrentDept. Cell Biology & Gentics Faculty Recruit Committee
LocalSchool/Insitutional CommitteesCommittee Member
2008 - CurrentThe North Texas Eye Research Institute
LocalUNTHSC Sponsored ActivitiesDirector
2008 - CurrentUNTHSC Postdoc Committee
LocalSchool/Insitutional CommitteesCommittee Member
Professional Service   More...    Close... 
2013 - CurrentMolecular Neurodegeneration
InternationalEditorial Review Boards/Study SectionsEditor
2012 - CurrentMolecular Vision
InternationalEditorial Review Boards/Study SectionsEditor
2012 - CurrentJoournal of Ocular Pharmacology & Therapeutics
InternationalEditorial Review Boards/Study SectionsEditor
2008 - CurrentExperimental Eye Research
InternationalEditorial Review Boards/Study SectionsEditor
2007 - CurrentAmerican Health Assistant Foundation - Glaucoma Research
InternationalJournal/Grant ReviewerCommittee Member
2007 - CurrentExperimental Eye Research
InternationalJournal/Grant ReviewerPeer Reviewer
2007 - CurrentIOVS
InternationalJournal/Grant ReviewerPeer Reviewer
1998 - CurrentMolecular Vision
InternationalJournal/Grant ReviewerPeer Reviewer
2012 - 2012ISER
InternationalCME Lectures / Training SeminarsOrganizer
2011 - 20112011 AOPT Meeting
InternationalCME Lectures / Training SeminarsChairman
Community Service   More...    Close... 
2012 - CurrentNTERI - eye glass collection
LocalOther Volunteer ActivitiesDirector
2014 - 2014Arlingtom AISD - hands-on science classes for 6th graders
LocalOther Volunteer ActivitiesMember
2013 - 2013AISD - Career Day at Bergin Elementary School
LocalOther Volunteer ActivitiesVolunteer
2012 - 2012Arlington Independent School District - career day at Bergin Elementary
LocalOther Volunteer ActivitiesMentor
2010 - 20102nd grade hands-on science course at Corey Elementary, AISD
LocalOther Volunteer ActivitiesLecturer
2009 - 2009Prevent Blindness Texas - Light the Night for Sight
LocalOther Volunteer ActivitiesMember
2008 - 2009Hands-on science labs for elementary students - AISD
LocalOther Volunteer ActivitiesVolunteer
2007 - 2008American Journal of Physiology
InternationalJournal/Grant ReviewerPeer Reviewer
2007 - 2007Medical Science Monitor
InternationalJournal/Grant ReviewerPeer Reviewer
2007 - 2007Fight for Sight (UK)
InternationalJournal/Grant ReviewerGrant Reviewer
 
Additional Information
Biographical Sketch

Dr. Clark is Professor and Executive Director of the North Texas Eye Research Institute. aHis research interests are focused on understdiscovering the biochemical, cellular and molecular mechanisms involved in the pathobiology of glaucoma and other ocular diseases. His research focuses on the trabecular meshwork, optic nerve head, and retinal ganglion cells. His collaborates with laboratories throughout the US as well as internationally.

 
Last Updated: May 31st 2016